User:Biomedpro/FAP (protein)

Fibroblast activation protein, alpha (FAPalpa, FAP, seprase), is a membrane bound protease.

FAP a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis.

definition and function
Fibroblast activation protein (FAP, FAPalpha, seprase) is a post prolyl serine protease. It has dipeptidase and endopeptidase activity. FAP, also known as seprase, belongs to the clan SC proteases and is a member of the S9B prolyl oligopeptidase subfamily. Other members of the S9B subfamily are DPPIV, DPP8 and DPP9. FAP is most closely related to DPPIV and they share about 50% of there amino acids.

FAP is almost selectively expressed on activated fibroblasts in remodelling tissue. among these fibroblasts are many cancer associated from tumors such as ovarian, breast, colon, and gastric carcinoma. Numerous studies indicate the involvement of the enzyme in carcinogenesis.

FAP is catalytically active as a 170kDa dimer,