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= Hepatocellular Carcinoma: Draft of Details =

Etiology and Epidemiology
Epidemiology of Hepatocellular Carcinoma in the Asia-Pacific Region.

RX Zhu, WK Seto, CL Lai, MF Yuen - Gut and liver, 2016

Risk factors
Coffee and the risk of hepatocellular carcinoma and chronic liver disease: a systematic review and meta-analysis of prospective studies.

F Bravi, A Tavani, C Bosetti, P Boffetta, C La Vecchia - European Journal of Cancer …, 2016

Hepatitis B
Systematic review with meta‐analysis: development of hepatocellular carcinoma in chronic hepatitis B patients with hepatitis B surface antigen seroclearance

F Liu, XW Wang, L Chen, P Hu, H Ren, HD Hu - Alimentary Pharmacology & …, 2016

[PDF] Factors associated with postoperative HBV reactivation in HBV related hepatocellularcarcinoma patients with HBV-DNA levels less than the minimum

J Chen, T Bai, XB Wang, ZB Xie, JJ Liu, Y Zhang… - Int J Clin Exp Med, 2016

Abstract B37: Prevalence of viral hepatitis B and C infection among immigrants in the Baltimore-Washington metropolitan area screened from 2009-2014

E Ha, F Kim, J Pan, DTP Hong, HS Juon - Cancer Epidemiology Biomarkers & …, 2016

Hepatitis C
[PDF] Early detection of hepatocellular carcinoma co-occurring with hepatitis C virus infection: A mathematical model

ARN Zekri, ASED Youssef, YM Bakr, RM Gabr… - World J Gastroenterol, 2016

Abstract A22: Programmatic implementation of hepatocellular carcinoma prevention through hepatitis C testing, secondary prevention, and treatment for a medically …

SE Dobra, N Baker, L Miller, L Stokes - Cancer Epidemiology Biomarkers & …, 2016

Pathogenesis
[HTML] Diverse Basis of β-Catenin Activation in Human Hepatocellular Carcinoma: Implications in Biology and Prognosis

H Okabe, H Kinoshita, K Imai, S Nakagawa, T Higashi… - PLOS ONE, 2016

Focal loss of long non-coding RNA-PRAL, as determinant of cell function and phenotype ofhepatocellular carcinoma

F Feo, MM Simile, RM Pascale - Annals of Translational Medicine, 2016

A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinomaformation.

X Li, X Qian, LX Peng, Y Jiang, DH Hawke, Y Zheng… - Nature cell biology, 2016

[HTML] Elastin Fiber Accumulation in Liver Correlates with the Development of HepatocellularCarcinoma

Y Yasui, T Abe, M Kurosaki, M Higuchi, Y Komiyama… - PLOS ONE, 2016

[PDF] Overexpression of variant PNPLA3 gene at I148M position causes malignant transformation of hepatocytes via IL-6-JAK2/STAT3 pathway in low dose free fatty acid …

Z Liu, T Chen, X Lu, H Xie, L Zhou, S Zheng - Am J Transl Res, 2016

The regulation of CD44 expression by new tumor suppressor gene Arid2 and the influence of Arid2 on the invasion and metastasis in hepatocellular carcinoma cells

L Tian, YJ Duan, LZ Nie, Z Li, Z Chen, QZ Gao, Y Yang… - Zhonghua gan zang bing za …, 2016

[HTML] Global, cancer-specific microRNA cluster hypomethylation was functionally associated with the development of non-B non-C hepatocellular carcinoma

M Nojima, T Matsui, A Tamori, S Kubo, K Shirabe… - Molecular Cancer, 2016

Genetic Lineage Tracing Analysis of the Cell of Origin of Hepatotoxin-Induced Liver Tumors in Mice.

S Shin, KJ Wangensteen, M Teta-Bissett, YJ Wang… - Hepatology (Baltimore, Md.), 2016

[HTML] Oncogenic mutations and dysregulated pathways in obesity-associated hepatocellularcarcinoma

J Shen, H Tsoi, Q Liang, ESH Chu, D Liu, ACS Yu… - Oncogene, 2016

Human growth hormone and human prolactin function as autocrine/paracrine promoters of progression of hepatocellular carcinoma.

X Kong, W Wu, Y Yuan, V Pandey, Z Wu, X Lu… - Oncotarget, 2016

[HTML] … methylation analysis reveals distinct association between PAX6 methylation and clinical characteristics with different viral infections in hepatocellular carcinoma

YL Shih, CC Kuo, MD Yan, YW Lin, CB Hsieh… - Clinical Epigenetics, 2016

Mechanisms of HBV-induced hepatocellular carcinoma

M Levrero, J Zucman-Rossi - Journal of Hepatology, 2016

Clinical Manifestations
Solitary Mediastinal Lymph Node Metastasis From Hepatocellular Carcinoma

H Tanaka, N Yamazaki, H Watanabe, M Nakade - Kyobu geka. The Japanese journal …, 2016

Staging, Diagnosis and Biomarkers
[HTML] Development and validation of a new prognostic system for patients with hepatocellularcarcinoma

F Farinati, A Vitale, G Spolverato, TM Pawlik, YH Lee… - PLoS Med, 2016

Background Prognostic assessment in patients with hepatocellular carcinoma (HCC)

Integrative Biomarker Analyses Indicate Etiological Variations in Hepatocellular Carcinoma

AX Zhu, D Chen, W He, M Kanai, M Voi, LT Chen… - Journal of Hepatology, 2016

URINARY METABOTYPING OF HEPATOCELLULAR CARCINOMA IN A UK COHORT USING PROTON NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

MIF Shariff, JU Kim, NG Ladep, MME Crossey… - Journal of Clinical and …, 2016

[PDF] High expression of miR-20a predicated poor prognosis of hepatocellular carcinoma

CL Ma, S Qiao, XF Wang, RJ Sun, X Zhang, YC Li… - Int J Clin Exp Med, 2016

A genetic database can be utilized to identify potential biomarkers for biphenotypic hepatocellularcarcinoma-cholangiocarcinoma

SRS Mok, S Mohan, N Grewal, AB Elfant, TA Judge - Journal of Gastrointestinal …, 2016

[HTML] [http://scholar.google.ca/scholar_url?url=http://journals.plos.org/plosmedicine/article%3Fid%3D10.1371/journal.pmed.1002005&hl=en&sa=X&scisig=AAGBfm3niHRfLlD1M-BYuBADJgw9zE4GPg&nossl=1&oi=scholaralrt The ITA. LI. CA Staging System: A Novel Staging System for Hepatocellular Carcinoma]

ND Parikh, AG Singal - PLOS Med, 2016

Evaluation of Sorafenib for Hepatocellular Carcinoma with Low c-Fetoprotein by Arrival Time Parametric Imaging Using Contrast-Enhanced Ultrasonography with …

K Shiozawa, M Watanabe, T Ikehara, Y Matsukiyo… - Gan to kagaku ryoho. …, 2016

Rhamnetin induces sensitization of hepatocellular carcinoma cells to a small molecular kinase inhibitor or chemotherapeutic agents

H Jia, Q Yang, T Wang, Y Cao, Q Jiang, H Sun, M Hou… - Biochimica et Biophysica …, 2016

Management
No Need of Immediate Treatment for Hypovascular Tumors Associated with HepatocellularCarcinoma

Y Midorikawa, T Takayama, S Nara, T Hashimoto… - World Journal of Surgery, 2016

Bridging and downstaging therapy in patients suffering from hepatocellular carcinoma waiting on the list of liver transplantation

WH She, TT Cheung - Translational Gastroenterology and Hepatology, 2016

Changes of HBV DNA After Chemoembolization for Hepatocellular Carcinoma and the Efficacy of Antiviral Treatment

XJ Lin, XM Lao, M Shi, SP Li - Digestive Diseases and Sciences, 2016

Benefits from mTOR inhibitor use in liver transplant recipients with hepatocellular carcinoma: The story has just begun

EK Geissler, AA Schnitzbauer, HJ Schlitt - Liver Transplantation, 2016

Locoregional Treament:
Optimal surgical strategy for hepatocellular carcinoma with portal vein tumor thrombus: A propensity score analysis.

YF Zhang, Y Le, W Wei, RH Zou, JH Wang, HY OuYang… - Oncotarget, 2016

Survival Benefit of Locoregional Treatment for Hepatocellular Carcinoma with Advanced Liver Cirrhosis

Percutaneous treatment of extrahepatic recurrence of hepatocellular carcinoma

A Doreille, G N'Kontchou, A Halimi, F Bouhafs… - … and Interventional Imaging, 2016

Radiofrequency ablation for recurrent versus first occurrence hepatocellular carcinoma

CCN Chong, J Wong, YS Cheung, SCH Yu, JWY Hui… - Surgical Practice, 2016

[PDF] Comparative Efficacy of Interventional Therapies for Early-stage Hepatocellular Carcinoma: A PRISMA-compliant Systematic Review and Network Meta-analysis

T Lan, L Chang, MN Rahmathullah, L Wu, YF Yuan - Medicine, 2016

Systemic Therapy:
[PDF] Antiviral therapy for hepatitis B virus-related hepatocellular carcinoma after surgery: A comment for moving forward

JH Zhong, T Yang, BD Xiang, LQ Li, L Ma - World, 2016

… 6 supplementation might mediate antioxidant capacity by reducing plasma homocysteine concentration in patients with hepatocellular carcinoma after tumor resection

YC Huang, SB Cheng, HT Liu - The FASEB Journal, 2016

Randomized Phase II placebo controlled study of codrituzumab in previously treated patients with advanced hepatocellular carcinoma

GK Abou-Alfa, O Puig, B Daniele, M Kudo, P Merle… - Journal of Hepatology, 2016

Randomized, Open-Label Phase 2 Study Comparing Frontline Dovitinib vs Sorafenib in Patients With Advanced Hepatocellular Carcinoma.

AL Cheng, S Thongprasert, HY Lim… - Hepatology (Baltimore, Md.), 2016

A Phase 1, First-in-Human Study of AMG 780, an Angiopoietin-1 and-2 Inhibitor, in Patients With Advanced Solid Tumors

A Dowlati, G Vlahovic, R Natale, E Rasmussen, I Singh… - Clinical Cancer Research, 2016

[HTML] A phase I study of the human anti‐activin receptor‐like kinase 1 antibody PF‐03446962 in Asian patients with advanced solid tumors

KH Lee, TM Kim, A Ohtsu, TY Kim, M Ikeda, K Yoh… - Cancer Medicine, 2016

MEK inhibitor treatment is effective in a patient with metastatic carcinoma of the ampulla of Vater with BRAF and NRAS mutations shown by next-generation …

E Tahover, RB Shalom, N Bogot, D Kelsen, A Gabizon - Anti-Cancer Drugs, 2016

Sorafenib
Diaryl Urea: a Privileged Structure in Anticancer Agents.

L Garuti, M Roberti, G Bottegoni, M Ferraro - Current medicinal chemistry, 2016

[HTML] Safety and efficacy of sorafenib in Japanese patients with hepatocellular carcinoma in clinical practice: a subgroup analysis of GIDEON

M Kudo, M Ikeda, T Takayama, K Numata, N Izumi… - Journal of Gastroenterology, 2016

Exceptional Responders
A Case of Complete Remission in Patient with Extrahepatic Metastasis after Curative Resection ofHepatocellular Carcinoma by Radiotherapy, Lung Resection and …

YJ Kim, HW Lee, JH Lee, JS Sung, DY Kim - Journal of Liver Cancer, 2016

Drug Development
[PDF] Inhibition of wnt/β-catenin Signaling in Hepatocellular Carcinoma by an Antipsychotic Drug Pimozide

V Fako, Z Yu, CJ Henrich, T Ransom, AS Budhu… - International Journal of …, 2016

[HTML] Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7

SO Sajadian, C Tripura, FS Samani, M Ruoss… - Clinical Epigenetics, 2016

Correction: Krüppel-like Factor 4, a Tumor Suppressor in Hepatocellular Carcinoma Cells Reverts Epithelial Mesenchymal Transition by Suppressing Slug Expression

ZS Lin, HC Chu, YC Yen, BC Lewis, YW Chen - PLOS ONE, 2016

Polysaccharide from Lentinus edodes combined with oxaliplatin possesses the synergy and attenuation effect in hepatocellular carcinoma

Y Zhang, Q Li, J Wang, F Cheng, X Huang, Y Cheng… - Cancer Letters, 2016

[HTML] Smad3 Sensitizes Hepatocelluar Carcinoma Cells to Cisplatin by Repressing Phosphorylation of AKT

HH Zhou, L Chen, HF Liang, GZ Li, BX Zhang… - International Journal of …, 2016

[HTML] Therapeutic Injection of a C-Type CpG ODN Induced an Antitumor Immune Response in C57/BL6 Mice of Orthotopically Transplanted Hepatocellular Carcinoma

H Jia, T Zhao, D Zou, X Jia, J Gao, X Song - Oncology Research Featuring Preclinical …, 2016

Knockdown of alpha-fetoprotein expression inhibits HepG2 cell growth and induces apoptosis

X Yang, L Chen, Y Liang, R Si, Z Jiang, B Ma, P Gao - 2016

[HTML] TTF1-NPs Induce ERS-Mediated Apoptosis and Inhibit Human Hepatoma Cell Growth In Vitro and In Vivo

B Xiao, C Liu, B Liu, X Zhang, R Liu, XW Zhang - Oncology Research Featuring …, 2016

17β-estradiol exerts anticancer effects in anoikis-resistant hepatocellular carcinoma cell lines by targeting IL-6/STAT3 signaling

S Lee, M Lee, JB Kim, A Jo, EJ Cho, SJ Yu, JH Lee… - … and Biophysical Research …, 2016

[PDF] Up-Regulation of PAI-1 and Down-Regulation of uPA Are Involved in Suppression of Invasiveness and Motility of Hepatocellular Carcinoma Cells by a Natural …

X Wang, N Wang, H Li, M Liu, F Cao, X Yu, J Zhang… - International Journal of …, 2016

HCC Models
[PDF] Adult mouse model of early hepatocellular carcinoma promoted by alcoholic liver disease

A Ambade, A Satishchandran, B Gyongyosi, P Lowe… - World J Gastroenterol, 2016