User:Bjenquin12/sandbox

= NBPF19 = Neuroblastoma breakpoint family, member 19, or NBPF19, is a protein that is encoded by the gene NBPF19 in humans. This protein is included in the neuroblastoma breakpoint family of proteins.

Gene
The NBPF19 gene in humans is composed of 80,464 bases including introns and exons. It is located on the positive strand of chromosome 1 at locus 1q21.2.

Transcript
The mRNA transcript of NBPF19 in humans is 13,190 bases long. There are 2 predicted alternative splicing isoforms, although none have been observed.

Protein
The protein product of the NBPF19 transcript is composed of 3,843 amino acids and weighs 440.4 kD. The NBPF19 protein contains 45 DUF1220 domains of unknown function but that have been linked to evolutionary changes and generally decrease in number in species more evolutionarily distant from humans.

Post-translational modifications
NBPF19 is expected to undergo many post-translational modifications, most notably phosphorylation and sumoylation. The protein is extensively phosphorylated on serine, threonine, and tyrosine residues in a repetitive pattern shown in the above figure. There are 14 repeats within the sequence thought to be sites of sumoylation.