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The B CUBE - Center for Molecular Bioengineering is a research facility and part of the Center for Molecular and Cellular Bioengineering (CMCB), a central scientific unit of the TU Dresden. Research at the B CUBE aims to learn from nature and translate the new knowledge into technological applications.

History
The B CUBE was founded in 2008 as “Center for Innovation Competence B CUBE” funded by the Federal Ministry of Education and Research (BMBF) within the program “Unternehmen Region”. The concept behind the research at the B CUBE, learning from nature to create novel technological applications, was developed by Prof. Carsten Werner, Prof. Christoph Neinhuis, and Prof. Daniel Müller.

From 2010 to 2018, the B CUBE was located in the Arnoldstraße, before it was relocated into a new building on Tatzberg which is shared with the German Center for Neurodegenerative Diseases (DZNE). The entrance to the building is decorated with the sculpture “Gittergeflecht”, inspired by images of organic sculptures and created by the artist Frank Schauseil from Dresden. The new building is located in the vicinity of Biotechnology Center (BIOTEC), the Center for Regenerative Therapies Dresden (CRTD) and the University Hospital Carl Gustav Carus Dresden.

In 2016, the B CUBE together with the BIOTEC and the CRTD became part of the Center for Molecular and Cellular Bioengineering (CMCB), a newly founded central scientific unit of the TU Dresden.

Research focus
The research conducted at the B CUBE is interdisciplinary and follows the idea of learning from nature. By gaining a deeper understanding of the mechanisms of natural phenomena and translating the new findings into technological applications, the B CUBE wants to build bridges between life sciences and engineering sciences.

The research focus of the B CUBE can be divided into:
 * Bioprospecting: the search for natural phenomena which can be exploited for technological applications
 * BioNano tools: developing and using nanometer-sized tools for the characterization and manipulation of biological structures and processes at the molecular level
 * Biomimetic materials: characterization of biomaterials and research into natural production processes

The name B CUBE derives from “B” being a common first letter of the three areas of research, thus B^3 or B CUBE.

Currently seven different research groups are housed in the B CUBE:
 * Molecular Transport in Cell Biology and Nanotechnology led by Prof. Dr. Stefan Diez
 * Biomineralization and Bio-enabled Materials Synthesis led by Prof. Dr. Nils Kröger
 * Chitin-based Biological Materials and Biomineralization led by Prof. Dr. Yael Politi
 * Bottom-up Synthetic Biology led by Dr. James P. Sáenz
 * Molecular Biophysics: Conformational Dynamics of Biomolecules led by Prof. Dr. Michael Schlierf
 * Bioresponsive Materials led by Prof. Dr. Yixin Zhang
 * Multi-Scale Analysis led by Dr. Igor Zlotnikov

Teaching
As part of the CMCB, a central scientific unit of the TU Dresden, the B CUBE is involved in teaching in Bachelor Courses, as well as in the Master’s programs offered by the CMCB.

It is also possible to complete a PhD at the B CUBE, either in the Dresden International Graduate School for Biomedicine and Bioengineering (DIGS-BB) or as Bioscience PhD Student (BiPS).

Facilities
The B CUBE contributes to the CMCB Technology Platform. In the CMCB Technology Platform various services from the field of Life Science are centralized in several core facilities. The facilities and services are available to all scientists at the TU Dresden and cooperating institutes.

Cooperations & Partners
The most important partners of the B CUBE are the two other institutes of the CMCB, the BIOTEC and the CRTD. Other partner institutions of the B CUBE in Dresden are the Excellence Cluster Physics of Life at the TU Dresden, the School of Science at the TU Dresden, the Faculty of Mechanical Science and Engineering at the TU Dresden, the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG), the Max Planck Institute for the Physics of Complex Systems (MPI-PKS), and the Leibniz Institute for Polymer Research Dresden (IPF).

Until 2021, the research at the B CUBE gave rise to two spin-off companies: DyNAbind GmbH and denovoMATRIX GmbH.

Other
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