User:Bob K31416/IB

Interaction with aspirin
Ibuprofen may suppress the anti-platelet effect of aspirin. Some people who are at risk for heart attack or stroke, benefit from a small daily dose of aspirin to reduce the risk of blood clots that cause heart attack and stroke. Aspirin prevents platelets from forming clots by irreversibly binding to the cyclooxegenase (COX) enzyme of platelets. If ibuprofen is present in the blood, it can bind to the COX before the aspirin does, and thus prevent the aspirin from binding to the COX. Like aspirin, the binding of ibuprofen to COX prevents the platelet from clotting, but unlike aspirin which permanently binds to a COX, the ibuprofen binds only temporarily and the platelet becomes available again for clotting when the ibuprofen leaves the binding site. Depending on when the ibuprofen is ingested, it may bind to the COX long enough so that the aspirin is excreted from the body without any beneficial anti-platelet activity.

Schuijt2009 - The interaction of ibuprofen and diclofenac with aspirin in healthy volunteers

Gengo2008 – Effects of Ibuprofen on the Magnitude and Duration of Aspirin's Inhibition of Platelet Aggregation: Clinical Consequences in Stroke Prophylaxis

UB2008 – Ibuprofen Destroys Aspirin's Positive Effect on Stroke Risk

Bloom2006 – FDA Cautions on Mixing Ibuprofen and Aspirin

FDA2006 – Information for Healthcare Professionals: Concomitant Use of Ibuprofen and Aspirin

FDA2009 – New Information about Taking Ibuprofen and Aspirin Together

FDApaper2006 – Concomitant Use of Ibuprofen and Aspirin: Potential for Attenuation of the Anti-Platelet Effect of Aspirin

Mason2005 – Aspirin Resistance and Atherothrombotic Disease

Catella-Lawson2001 PubMed – Cyclooxygenase inhibitors and the antiplatelet effects of aspirin

RXMED – Aspirin (half-life of 3.5–4.5 hours)

Search: Cyclooxygenase inhibitors and the antiplatelet effects of aspirin

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