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DNA Software has developed the industry’s most powerful software tool for modeling nucleic acid hybridization, the Oligonucleotide Modeling Platform (OMP). OMP is the engine that drives all of DNA Software’s oligonucleotide design and simulation software products. It was developed based on the pioneering work of DNA Software’s Chief Executive Officer, Dr. John SantaLucia, whose research group at Wayne State University has been instrumental in developing the Nearest Neighbor model of DNA hybridization.

What sets DNA Software’s Oligonucleotide Modeling Platform apart?
DNA Software’s Oligonucleotide Modeling Platform is industry’s most accurate tool for simulation of oligonucleotide hybridization. Although several oligonucleotide design tools use the Nearest Neighbor model to predict the melting temperature of oligonucleotide duplexes, these tools implement the simplistic two-state model of hybridization that does not account for the myriad potential interactions in a real system. Only the Oligonucleotide Modeling Platform (OMP) implements the Multistate Coupled Equilibrium model of hybridization, enabling hybridization simulations that account for every possible hybridization event in a given system with unparalleled accuracy.

OMP’s thermodynamic calculations are based on its proprietary database of thermodynamic parameters-—the industry’s most comprehensive thermodynamic database, which accounts for the thermodynamic effects of nucleic acid structural motifs, fluorophores and quenchers, buffer additives, modified nucleotides, and more.