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Clay's Ark
Clay's Ark (1984) is a novel by American science fiction author Octavia E. Butler. The last published of her Patternist series, the novel serves as a prequel that accounts for the arrival of the Clay Ark disease that leads to the evolution of clayarks, the mutants that threaten human survival in the other books in the series.

Plot
The novel is set in a near-future dystopia in which most people must live in gated communities or in armed nomadic groups called "car families." The novel traces the experiences of Blake Maslin, a physician living in Southern California, and his sixteen-year-old twin daughters, Rane and Keira. Traveling across a Mojave desert, the three are kidnapped by Eli Doyle, the only survivor of Clay's Ark, a spaceship that made an emergency crash landing in the desert on its return from the first manned mission to another planet. Eli is infected with an alien microorganism that gives him heightened sensory and physical powers, but also directs his actions toward its own survival and transmission. He has assembled a "family" on a small isolated ranch, hoping to slow or stop the microorganism's transmission, but the urge to reproduce is so strong that he seeks out other humans to add to his family. Many infected young men or older women die of the disease, but infected women survive to give birth to sphinx-like offspring--intelligent quadrupeds with extraordinary speed. The mutants, eventually (in novels set later in the series) called clayarks, see uninfected humans as food but can also spread the microorganism through their bite. Blake, Rane, and Keira are infected and Eli expects them to join in the reproductive project of the community. Blake and his daughters flee, only to be captured by a "car family" with much more violent tendencies. Blake and Rane, drawn by the microorganism to seek out food and sex, are fatally injured by the "car family." Rane is decapitated, but Blake manages to escape long enough to infect a long-haul truck driver, making inevitable the spread of the disease through the rest of the country and eventually the world. Keira, having been cured of leukemia by the microorganism, reluctantly agrees to participate and returns with Eli to the ranch family, pregnant with her own mutant child.