User:Booktester/sandbox

Lyubov Yablochnik (Russian: Любовь Марковна Яблочник; December 8, 1928 – September 22, 2013) - Soviet and Russian veterinary microbiologist.

Life and career
Lyubov Yablochnik was born in 1928 in Bryansk, Soviet Union. In 1951 she graduated from the Moscow State University of Food Production and worked as veterinary physician in Krasnoyarsk Krai until 1954.

In 1957—1960 she was junior research fellow in M.P.Chumakov Institute of Poliomyelitis and VIral Encephalitides (Moscow, USSR). In 1960—1963 she worked as microbiologist engineer at Moskhimfarmpreparaty OAO Im. N.A. Semashko.

At 34, when she was already the mother of two children, L. M. Yablochnik decided to engage in scientific work. To this end, she completed a full course of microbiology at the eponymous department of the First Moscow State Medical University, and in 1963 she entered the postgraduate program of the All-Russian Scientific Research Institute of Experimental Veterinary Medicine (VIEV) - in the laboratory of mycology and antibiotics.

Since 1966 she worked as Researcher, and since 1973 - Senior Researcher at the All-Russian Scientific Research Institute of Experimental Veterinary Medicine.

At the end of 1973, she transferred to the All-Union State Research Control Institute for Veterinary Preparations (VGNKI) as the post of senior researcher in the laboratory of antibiotics. In 1978, with her leading participation, a laboratory for the control and standardization of preparations against mycoses was created, which she headed from 1981 to 1989.

From 1989 to 1993, Lyubov Yablochnik was a leading researcher in the laboratory for the control and standardization of probiotics, drugs against coccal infections and mycoses.

Since 1993 she lived with her family in the USA, in the states of New York and New Jersey.

Research
Admission to the postgraduate school of VIEV (in the laboratory of mycology and antibiotics) identified the main direction of research Lyubov Yablochnik - the study of mycosis (diseases caused by parasitic fungus) of farm animals.

Supervisor Professor A. Sarkisov (Russian: Саркисов, Арутюн) set the postgraduate student Yablochnik the task of studying immunity in trichophytosis (ringworm) of cattle. The studies conducted by L. Yablochnik on a group of experimental animals showed that animals that had recovered and were cured after reinfection did not become ill. The existence of immunity in diseases caused by microscopic fungi has been proven, and therefore the possibility of creating a vaccine against ringworm of cattle.

In 1969, for the first time in world practice, an antifungal vaccine was developed, a live culture of Trichophyton faviforme was developed as an immunogenic drug, the vaccine was called TF-130 its shelf life, and then improved - the vaccine TF-130 (K).

As a result of immunization of cattle in the Soviet Union with the new vaccine LTF-130 for the period 1968-1978, the disease Trichophytia was reduced more than 100-fold and practically disappeared.

The LTF-130 vaccine is by far the most effective biological drug used against cattle ringworm.

The work of Soviet scientists was highly appreciated both in the country (USSR State Prize –1973) and abroad. Vaccines TF-130 and LTF-130 have been patented in many countries around the world. Of particular note is the gold medal "Best invention of practical use to developing countries" by the World Intellectual Property Organization (WIPO), which the authors of the LTF-130 vaccine (Sarkisov A., Yablochnik L., Petrovich S., Nikiforov L.) received in 1983. Winners of such an award in the world less than the Nobel laureates. L. Yablochnik was the first female scientist from the Soviet Union to receive this awardundefined.

In 1992 under the leadership of L.M. Yablochnik has developed a vaccine against trichophytosis in animals.

Publications and Patents
Yablochnik L. M. Experimental study of immunity in trichophytia guinea pigs (In Russian). // Bulletin of VIEV - Moscow., 1967. - T.2.- P. 96-100.

Yablochnik L. M. Immunity in cattle trichophytosis: Dissertation of the candidate veterinary sciences (In Russian).// Bulletin of VIEV - Moscow., 1968. - P. 20.

USSR Inventor's Certificate No. 268593 for "Method of Specific Prophylaxis of Cattle Trichophytosis", 1970.

Sarkisov, S. V. Petrovitch, L. I. Nikiforov, L. M. Yablochnik, V. P. Koroleva "Immunization of Cattle against Trichophytosis", J. "Veterinary", 1971, 2, 54-56 (in Russian)..

Yablochnik L. Immunity in cattle trichophytosis. // Bulletin of VIEV - Moscow, 1972 - Выпуск 12 - P. 15-16.

[https://patents.google.com/patent/DK138803B/en?oq=DK138803B Patent DK138803B: A process for the preparation of a vaccine for the treatment of cattle against trichophytose. Inventor: Arutjun Khristoforovi Sarkisov, Svyatoslav Vsevolodo Petrovich, Lev Ivanovich Nikiforov, Ljubov Markovna Yablochnik. Original Assignee: V Iex Veterinarii. Priority date: 1972-05-29]

[https://patents.google.com/patent/CA984749A/en?oq=CA-984749-A Patent CA-984749-A: Method for producing preparation for prophylaxis of trichophytosis in cattle. Arutjun K. Sarkisov, Svyatoslav V. Petrovich, Lev I. Nikiforov, Ljubov M. Yablochnik. Vsesojuzny Ordena Lenina Institut Experimentalnoi Veterinarii. March 02, 1976]

[http://patents.su/?search=955570&type=number USSR Inventor's Certificate No. №955570. A method of manufacturing a vaccine against trichophytia cattle. Priority date: 26.03.80, Publication date: 07.11.1984. Inventor:: А.Х. Саркисов, Л.М. Яблочник, Л.И. Никифоров, C.B. Петрович, К.П. Летягин, Т.Н. Мохина, Г.Ф. Денисенко, И.И. Жарков, В.Ф. Ковалев, Ю.П. Чернецкий].

[http://patents.su/?search=955571&type=number USSR Inventor's Certificate №955571. Vaccine TF-130 (k) against cattle trichophytia and method of prophylaxis for cattle trichophytia treatment. Priority date: 28.03.80, Publication date: 07.11.1984. Inventor: А.Х. Саркисов, Л.М. Яблочник, С.В. Петрович, Л.И. Никифоров, И.И. Жарков, К.П. Летягин, Х.А. Джилавян, В.Г. Мельник].

[https://patents.google.com/patent/RU2013444C1/en Patent RU2013444C1 Strain of trichophyton mentagrophytes used for control of immunogenic activity of animal trichophytosis vaccines. Priority date: 1992-12-30. Publication date: 1994-05-30. Inventor: Л.М. Яблочник, А.Н. Панин, И.И. Жарков, К.П. Летягин].

[https://patents.google.com/patent/RU2013445C1/en?oq=RU2013445C1 Patent RU2013445C1. Strain of trichophyton mentagrophytes used for preparation of animal trichophytosis vaccine. Priority date: 1992-12-30. Publication date: 1994-05-30. Inventor: Л.М. Яблочник, А.Н. Панин, К.П. Летягин, К.А. Саркисов.]

[https://patents.google.com/patent/WO1994015632A1/en?oq=WO9415632-A1 Patent RU2018321C1; WO9415632-A1; AU9458245-A. Vaccine against trichophytosis in animals. Priority date: 1992-12-30. Publication date: 1994-08-30. Inventor: Ljubov Markovna Yablochnik, Karen Artemovich Sarkisov, Konstantin Pavlovich Letyagin, Alexandr Nikolaevich Panin]

[https://patents.google.com/patent/RU2074251C1/en?oq=RU2074251C1 Patent RU2074251C1 Strain of fungus trichophyton verrucosum used for preparing vaccine against animal dermatophytosis. Priority date: 1994-07-01. Publication date: 1997-02-27. Inventor: К.П. Летягин, Т.Н. Мохина, Л.М. Яблочник, А.Н. Панин, К.А. Саркисов]

Awards and Recognition

 * Recipients of the USSR State Prize (1973) - for the creation of a highly effective prophylactic drug TF-130 (vaccine) against ringworm cattle, the development of its production technology, the development of industrial production and the introduction into widespread veterinary practice.
 * WIPO Gold Medal. (June 1983) Invention: Method for production and use of the vaccine LTF-130, intended for prevention and treatment of cattle skin disease (Trichophytia). Prof. A.Kh.Sarkisov, Mr. S.V. Petrovich and Mr. L.I. Nikiforov were also part of the team that made this invention.
 * VDNKh (Russia). Gold Medal.