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3-carboxamido seco-nalmefene also known as 3CS-nalmefene is an opiate antagonist that treats opioid overdose.

Uses
Though the main use of 3CS-nalmefene is to be an opiate antagonist, the chemical is also shown to have antidepressant like effects and the use to help against severe cue-reactivity craving in people with alcohol use disorder.