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=Carbonic Anhydrase XIII= CA XIII is a cytoplasmic enzyme discovered in 2004 by sequence database analysis of humans and mice.

CA XIII is apart of a group of zinc-containing metalloenzymes that regulate pH in the tissues by reversible hydration of carbon dioxide. α-carbonic anhydrase occur in different areas. CA I, II, III, VI, XIII are located in the cytoplasm, while others are located in the membrane, mitochondria, or secreted. [1]

Structure
CA XIII has a globular shape similar to other α-CA. It consists of 10-stranded anti-parrellel β-sheets surrounded by several helices and additional β-strands.

Normal Expression
Lehtonen et al. studied the expression of CA XIII in human and mouse tissue using techniques, such as, reverse transcription polymerase chain reaction. In humans, CA XIII was located in the thymus, small intestine, testis, spleen, prostate, ovary, colon, not expressed in leucocytes. In mice, CA XIII in spleen, lungs, kidney, heart, brain, skeletal muscle, and testis. [1]

Pathological Conditions
CA XIII shows highest expression levels in testicular seninomas.