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Tetratricopeptide repeat 39A is a human protein encoded by the TTC39A gene. Other known aliases are TTC39A, differentially expressed in MCF7 with estradiol protein 6 (DEME-6), KIAA0452, and c1orf34. TTC39A is induced by TFAP2C in hormone responsive breast carcinoma cells and TTC39A is expressed in estrogen receptor positive carcinoma cell lines.

The TTC39A gene is located on the first chromosome at 1p32.3.



The genomic DNA is 57,859 bases long, consists of 19 exons and is located on the minus strand. The mRNA has a length of 2759 bases.

The longest protein sequence consists of 613 amino acids. Within TTC39A, there is a domain of unknown function, DUF 3808. DUF 3808 is generally considered to be an outer mitochondrial membrane protein and has been conserved from fungi to humans. DUF 3808 also contains a tetratricopeptide, TPR_16 and a predicted transmembrane domain.



= Homology = TTC39A has several orthologs that have been found in eukaryotes, archea, and bacteria. Two paralogs, TTC39B and TTC39C, have also been identified.

= Expression = There are 17 splice varients for TTC39A. TTC39A is highly expressed protein in the human body. The highest levels of expression are located in mammary glands and testis. The lowest levels of expression are found in the immune system.



=Protein Properties= TTC39A is predicted to have 12 alpha helices and a single beta sheet.

Post Translational Modifications
There are several predicted phosphorylation sites but none have been experimentally confirmed. A single sulfination site is predicted at position 175.

Interactions
TTC39A has been found to interact with butyrophilin-like 2 and Mapk3.

=Further Reading=

= References =