User:BreCaitlin/sandbox

I'm editing Wikipedia as part of this assignment and here's a link to my sandbox

SR proteins
SR proteins are a conserved family of splicing proteins rich in alternating arginine and serine protein residues. SR proteins are important in constitutive and alternative pre-mRNA splicing and some post splicing activities of mRNA. Proteins are classified as SR proteins if they have at least one RNA recognition motif (RRM) and one RS Domain. Other qualification include recognition by the antibody mAb104 and purification using magnesium chloride. In some cases a protein may lack the RRM domain, but is able to interact with RNA through other means. These proteins are called SR-related proteins. SR proteins are localized to the nucleus of cells, specifically in nuclear speckles.

SR proteins were discovered in the 1990's in Drosophila and around the same time in amphibian oocytes. Further investigation has found SR proteins in humans. In general, metazoans, multicellular organisms, appear to have SR proteins and unicellular organisms lack SR proteins.

SR proteins have RNA recognition sites at N- and C-terminus arginine and serine rich sites.

In plants it is thought that SR proteins play a role in development of specific tissues and responses to stress. SR proteins also have a role in regulating post-splicing mRNA metabolism and general mRNA metabolism.

SR proteins also bind to histone 3 tail to participate in transcriptional elongation to further organize gene expression not only at the RNA level, but also at the DNA level.