User:Bsridhar6/Grey Column Sandbox

A grey column is one of the three somewhat ridge-shaped masses of grey matter in the spinal cord. There are three types of grey columns: the anterior grey column, the posterior grey column, and the lateral grey column.

Anterior grey column
The anterior grey column, also known as the ventral horn, is made of three different types of neurons: large alpha motor neurons, medium gamma motor neurons, and small neurons thought to be interneurons. These neurons differ in both their morphology and in their patterns of connectivity. They are organized in the same manner as the muscles they innervate.

Alpha motor neurons
Alpha motor neurons innervate extrafusal muscle fibers that generate force at neuromuscular junctions at the start of muscle contraction. They have large cell bodies and receive proprioceptive input. They have been shown to reduce in population, but not in size with age. Damage to these cell bodies can lead to severe muscle weakness and loss of reflexes.

Gamma motor neurons
Gamma motor neurons innervate intrafusal muscle fibers that control the sensitivity of muscle spindles to stretch. They have smaller cell bodies than alpha motor neurons and do not receive proprioceptive input. They have been shown to reduce in numbers but not size with age.

Small neurons
The physiology of the small neurons in the anterior column is not well understood. Their effects can be both excitatory and inhibitory. They are suspected to be interneurons and have been shown to reduce in size but not numbers with age.

Related diseases
ALS has been shown to have an effect on neurons of the anterior column. The number of large alpha motor neurons and medium gamma motor neurons was greatly reduced and the number of small neurons was either slightly or greatly reduced depending on the type of ALS.

Muscular atrophy has also been shown to have an effect on neurons of the anterior column. A large loss of large alpha motor neurons, medium gamma motor neurons, and small neurons was recorded in cases of muscular atrophy.

Posterior grey column
The posterior grey column, also known as the dorsal horn, is divided into several laminae, based on the type of sensory information sent to each section. Laminae I and II are sent information from afferent neurons that sense pain, temperature, and itching, laminae III and IV are sent information neurons that sense mechanical pressure, and laminae V and VI are sent information from proprioceptors. It is known to be the primary relay point for haptic and nociceptive messages. The posterior horn is also known as a partially layered structure because only laminae I and II are well defined.

The column can also be separated by painful and non-painful senses. Laminae I and II are important in nociception, laminae III and IV are not involved nociception, and lamina V is involved in both nociception and non-nociception.

Lamina I
Lamina I is also known as the marginal nucleus of the spinal cord. The majority of posterior column projection neurons are located in lamina I, however most neurons in this layer are interneurons. The main areas these neurons innervate are the caudal ventrolateral medulla (CVLM), the nucleus of the solitary tract (NTS), the lateral parabrachial area (LPb), the periaqueductal grey matter (PAG), and certain regions in the thalamus. The CVLM receives nociceptive and cardiovascular responses. The NTS receives cardio-respiratory inputs and affects reflex tachycardia from noxious stimulation. The LPb projects to the amygdala and hypothalamus and is involved in the emotional response to pain. The PAG develops ways to deal with pain and is a main target of analgesics. It projects to other parts of the brainstem. The nuclei of the thalamus affect sensory and motivational aspects of pain. The neurons of this lamina can be distinguished by their morphology as pyramidal, fusiform, or multipolar.

Lamina II
This layer is also known as the substantia gelatinosa of Rolando and has the highest density of neurons. These neurons mediate the activity of pain and temperature afferent fibers. It is almost entirely made up of interneurons which can be further divided by their morphology. The four main morphological classes, based on the shape of their dendritic structure, are islet, central, vertical, and radial cells. The interneurons can also be divided by their function: excitatory or inhibitory. The excitatory interneurons release glutamine as their main neurotransmitter and the inhibitory interneurons use GABA and/or glycine as their main neurotransmitter. The neurons of this layer are only C fibers and contain almost no myelin.

Lamina III/IV
These laminae are also known as the nucleus proprius and contain a much smaller density of neurons than lamina II. There are projection neurons scattered throughout these layers. Mechanosensitive A beta fibers terminate in these layers. The layers receive input from lamina II and also control pain, temperature, and crude touch. C fibers that control pain and temperature and sensory information from mechanoreceptors are relayed here.

Lamina V
This lamina is also known as the neck of the posterior column and receives both non-painful information from mechanoreceptors and painful information from nociceptors. It has different neurons in different regions. In the medial region it contains medium sized triangular neurons and the lateral region contains medium sized multipolar neurons.

Lamina VI
This lamina is only found in the cervical and lumbar regions of the spinal cord. It receives afferent input from muscle fibers and joints.

Role in pain system
The posterior column is the first central relay in the pain pathway. The first order afferent neuron carries sensory information to the second order neuron in the dorsal horn. The axon of the second order neuron, if it is a projection neuron and not an interneuron, then goes to the third order neuron in the thalamus. The thalamus is known as the "gateway to the cortex". The third order neuron then goes to the cerebral cortex. The afferent neurons are either A fibers or C fibers. A fibers are myelinated allowing for faster signal conduction. Among these there are A beta fibers which are faster and carry information about non-painful touch and A delta fibers which are slower and thinner than the A beta fibers. The C fibers are not myelinated and therefore slower. C fibers that carry pain signals can be divided into two types: fibers that contain neuropeptides, like substance P, and fibers that do not contain neuropeptides. The two types terminate in very different areas. Non-peptidergic C fibers are linked to the skin, where they innervate the epidermis while peptidergic C fibers innervate other tissues and deeper parts of the skin.

There are two main types of pain signals: sensory and affective.

Sensory
Sensory pain signals provide information about what kind of stimulus (heat, mechanical, etc) is affecting the body and also indicates where on the body the stimulus is. Sensory pain neurons have a small receptive field to help pinpoint the exact location of a stimulus.

Affective
Affective pain signals affect emotions. These signals go to the limbic system and tell the body to react to the painful stimulus (i.e. removing a hand from a hot stove). These neurons have larger receptive fields because the emotional reaction to most pain stimuli is similar.

Lateral grey column
The lateral grey column is part of the sympathetic nervous system and receives input from brain stem, organs, and hypothalamus.

Related diseases
Horner's syndrome can be caused by damage to the lateral column. Multiple system atrophy (MSA) has also been linked to the lateral grey column. MSA has been shown to reduce the cell count in the lateral column by over 50%.