User:CJAmbrose/bergmann sandbox

 Note to reviewer 

We are currently editing the subsection Bergmann glia on the Astrocyte Wiki, as there is not a separate wikipedia page for this topic. If you see [ORIGINAL TEXT] followed by sentences in quotation, that is just indicating that we have copied and pasted parts of the original section (which is not great...) into the Sandbox so that we can edit/add information. Anything with a strikethrough is information from the original text that we will be removing.

-- Claudia, Sam, Nicole

Bergmann glia
Bergmann glia (also known as radial epithelial cells, Golgi epithelial cells, or radial astrocytes) are unipolar astrocytes derived from radial glia that are intimately associated with Purkinje cell s in the cerebellum. Bergmann glia have multiple radial processes that extend across the molecular layer of the cerebral cortex and terminate at the pial surface as a bulbous endfoot.

[ORIGINAL TEXT] "Bergmann glial cells form rows or palisades that are aligned to the long axis of folium characterized by high surface to volume ratio up to 20 micro-meters in rodent cerebellum there are 8 Bergmann glial cells per Purkinje Cell it has been estimated that each BGC operates around 2000-6000 Purkinje cell synapses. They occupy around 15%-18% of the molecular layer in cerebellum."

Bergmann glial cells assist with the migration of granule cells, guiding the small neurons from the external granular layer to the internal granular layer of the cerebral cortex along their extensive radial processes.

Bergmann gliosis
Bergmann gliosis (also known as Bergmann astrocytosis) refers to hyperproliferation of Bergmann glia in response to CNS injury or degeneration.

Role in Neurological Disorders
Following Purkinje cell death–a histological marker of several neurodegenerative disorders–Bergmann glia undergo extensive morphological and proliferative changes so as to replace lost or damaged tissue.