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Serum sickness is a type of allergic reaction to non-human proteins. Symptoms commonly include fever, rash, and joint pain. It generally occurs 7 to 14 days after exposure and symptoms can last for a few weeks. Complications are rare, though repeated episodes of serum sickness may potentially result in kidney failure.

Serum sickness is rare. It; however, may occur in up to 27% of people treated with thymoglobulin post kidney transplant. It was first described in detail by Clemens von Pirquet and Béla Schick in 1905.