User:Caroline.Alexandre59/sandbox

In a type of intracellular signaling referred to as the Nuclear Import process, cytosolic proteins like alpha and beta importins would bind the the nuclear localization sequence that is located within the protein, to which this complex would bind to a nuclear pore complex that allows for translocation into the nucleus. RanGTPase would bind to the beta importin which removes it from the complex, followed by the removal of the alpa importin which is also bound to the RanGTPase. While bound to the RanGTPase, the importins leave the nucleus where the Ran is hydrolyzed, converting the bound GTP into GDP. Ran-GDP can return the nucleus through its bind to a nuclear transport factor, where a Guanine Nucleotide Exchange Factor Protein can come to catalyze the exchange of GTP for GDP.