User:Cashmeresilk/sandbox

(2018) "Cyclin-K "

Though the page has some good information, the page is very scarce. Some images and videos would, as for me, help in understanding the protein's form and function. A slight description of Cyclin K's associate protein family of CDKs appear however can be misread as Cyclin K's function. Cyclin K when quickly googled is heavily directly associated with transcriptional regulation and cell development. The protein has also been studied under its association with HIV- 1 and it's necessary subunits such as CDK- 9, as well as a functional role in spermatogenesis. (2017) Autophagy-related protein 7 is a protein that in humans is encoded by the ATG7 gene.

Also known as GSA7; APG7L; APG7-LIKE.

ATG 7 is present in both plant and animal genome, an essential protein for cell degradation and the recycling. . A novel protein, ATG7 is associated with ubiquitin- proteasome system, UPS, required for unique autophagosomal membrane development and fusion.

In yeast cells, such as Pichia Pastorisn E1 activator protein within the UPS system, ATG 7 uses it’s cystine residue to create a thiol-ester bond with free Ubiquitin molecules. Through UPS, Ubiquitin will continue to bind to other autophagy-related proteins, E2 conjugation proteins and E3 protein ligases to attach Ubiquitins to a target substrate to be degraded.

ATG 7 is often associated with ATG 12/ ATG 5 sequence ubiquitination cascade. As well in presence of p53 cell cycle pathways during stressed/ nutrient poor environments.

''This gene was identified based on homology to Pichia pastoris GSA7 and Saccharomyces cerevisiae APG7. In the yeast, the protein appears to be required for fusion of peroxisomal and vacuolar membranes. The protein shows homology to the ATP-binding and catalytic sites of the E1 ubiquitin activating enzymes''