User:Caterina10anna5

Ledipasvir/Sofosbuvir
Currently added sections in the drug box: pubchem id, molecular formula, molar mass, and melting point range. Added additional sections on resistance, drug interactions, mechanisms of action, and pharmacokinetics. (Will also add a picture of the drug).

If you'd like to see current edits, please see Ledipasvir/sofosbuvir edit history.

Currently in the process of making new edits in my sandbox.

Peer review
 Cynthia’s review 

Overall I find this article really “scientific”, which means that if I’m not the patient or the physician, I would probably not read it. For most of the patients, also, they might not be able to understand many of the mechanisms mentioned in the article. So I guess to them, the more important information is the basic ones that should be able to be found in the drug instructions. My advice is that the information that is both basic and not able to be found in instructions might need to be emphasized in this article.

However, the editors did a good job in organizing all the related information and providing citations such that it does not seem so overwhelming to me. Especially for the “Resistance” part, I found the mutations on amino acids related to our Chem153A class, even though there’s no further information about how these mutations would influence specific mechanisms (which might seem a little too much anyways, if just to relate to our class). Good job! Here are some problems that I noticed for your information:
 * Content
 * 1) Lead section, after “ Ledipasvir works by decreasing the activity of NS5A and sofosbuvir works by decreasing the activity of NS5B polymerase.[1]”, you might briefly explain (maybe just one sentence) what NS5A and NS5B polymerase do in the disease.
 * 2) The editor(s) did a great job in organizing the “pharmacokinetics” section
 * Accuracy
 * 1) About “ the most effective and safe medicines needed in a health system” in leading section, the “most” seems quite unsupported to me, maybe the editor can use a more neutral word.
 * Organization
 * 1) Should the “Resistance” in “Medical uses” section be in a separate section? Or is it just intended to be in that section? The word is larger than normal is not a heading. It’s a little bit confusing.
 * Clarity
 * 1) Some of the scientific terms such as “polymorphism” might need to be briefly explained, since it is mentioned a lot in the mutation part.
 * 2) For the “Drug interactions” part, where can the “drug transporters” mentioned be found in the body? Are they some other medication or just naturally present in the body and if so, where? I found this part not well explained such that I don’t see the importance of this section. i.e. how should patients who need information for this drug interpret this section? Its importance should be clear if the editor explain what’re these drug transporters’ function in this mechanism.

 Hayley’s review 

Hello! I just wanted to say that your article was excellent overall. There are just a few minor edits I would consider to help improve it.

Strengths: Improvements:
 * Great organization
 * Variety of content
 * Definitions/links
 * Some sentences are verging on too technical - make sure that all words are well defined/ understood in context. One example of a sentence that seemed to technical was "The specific baseline NS5A resistance-associated polymorphisms observed in clinical trials were M28T/V, Q30H, Q30R, L31M, H58P, Y93H, and Y93N in Genotype 1a and L28M, A92T, and Y93H in genotype 1b." Great information from a research perspective, but these letter/number combinations don't mean a great deal to the average reader without further explanation.
 * The pharmacokinetics section has great information but is too technical overall. Expand on your explanation so that the average high schooler can comprehend the information!
 * Add more information to the "society and culture" section if possible
 * Collapse smaller sections to convey "big picture" ideas more effectively