User:Cayley P/COX-2 inhibitor

Cancer[edit]

COX-2 appears to be related to cancers and abnormal growths in the intestinal tract. Overexpression of COX-2 produces excess prostaglandins which have been shown to increase the possibility of colorectal cancer. COX inhibitors have been shown to reduce the occurrence of cancers and pre-cancerous growths. The National Cancer Institute has done some studies on COX-2 and cancer. The FDA has approved Celebrex for treatment of familial adenomatous polyposis (FAP). COX-2 inhibitors are currently being studied in breast cancer and appear to be beneficial.

Neuropsychiatric disorders[edit]

COX-2 inhibitors have been found to be effective in suppressing inflammatory neurodegenerative pathways in mental illness, with beneficial results in trials for major depressive disorder as well as schizophrenia.

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Cancer Paragraph

COX- 2 appears to be related to cancers and abnormal growths in the intestinal tract. Overexpression of COX-2 produces excess prostaglandin E2, which has been shown to increase the possibility of colorectal cancer. COX inhibitors have been shown to reduce the occurrence of cancers and pre-cancerous growths. The National Cancer Institute has done some studies on COX-2 and cancer'''. COX-2 can act as an anti-tumor enzyme, but only in specific cases.''' The FDA has approved Celebrex for treatment of familial adenomatous polyposis (FAP). COX-2 inhibitors are currently being studied in breast cancer and appear to be beneficial.

Neuropsychiatric disorders

COX-2 inhibitors have been found to be effective in suppressing inflammatory neurodegenerative pathways in mental illness, with beneficial results in trials for major depressive disorder as well as schizophrenia,bipolar affective disorder, and obsessive compulsive disorder.

Current studies support an association of disorders such as these with chronic inflammation, which appears to decrease with the use of COX-2 inhibitors