User:Cayley P/Choose an Article

Article Selection
Please list articles that you're considering for your Wikipedia assignment below. Begin to critique these articles and find relevant sources.

Option 1

 * Prostaglandin-endoperoxide synthase 2
 * Article Evaluation
 * This article has a lot of information already, but if I am thinking of concentrating on adding things about COX-2 activity in cancers, I could add the the Clinical Significance portion on the bottom.
 * This article has a lot of information already, but if I am thinking of concentrating on adding things about COX-2 activity in cancers, I could add the the Clinical Significance portion on the bottom.


 * Sources
 * Callan OH, So OY, Swinney DC (February 1996). "The kinetic factors that determine the affinity and selectivity for slow binding inhibition of human prostaglandin H synthase 1 and 2 by indomethacin and flurbiprofen". J. Biol. Chem. 271 (7): 3548–54. doi:10.1074/jbc.271.7.3548. PMID 8631960. (Possibly good because it goes off of the little information I have about cyclooxygenase and medications)

Option 2

 * COX-2 inhibitor
 * Article Evaluation
 * There is a box at the top of the page that gives the option to "Improve this article" which means there is probably a lot of information missing and it may be an easy one to add to if I want to keep the spectra of my research broad. The first paragraph is also related to COX-2 and its role in certain cancers. I could add to this portion, or maybe add a whole new section about a different type of illness related to COX-2 inhibition or expression.
 * There is a box at the top of the page that gives the option to "Improve this article" which means there is probably a lot of information missing and it may be an easy one to add to if I want to keep the spectra of my research broad. The first paragraph is also related to COX-2 and its role in certain cancers. I could add to this portion, or maybe add a whole new section about a different type of illness related to COX-2 inhibition or expression.


 * Sources
 * Lipfert, Peter; Seitz, Ruediger; Arndt, Joachim O. (1987). "Studies of Local Anesthetic Action on Natural Spike Activity in the Aortic Nerve of Cats". Anesthesiology. Ovid Technologies (Wolters Kluwer Health). 66 (2): 210–213. doi:10.1097/00000542-198702000-00016. ISSN 0003-3022. PMID 3813081. Non-steroidal anti-inflammatory drugs (NSAIDs) are the competitive inhibitors of cyclooxygenase (COX), the enzyme which mediates the bioconversion of arachidonic acid to inflammatory prostaglandins (PGs). (Definitely a good resource to check out whether this becomes my topic of not, because of my interest in non-steroidal drugs, and my love of cats.)

Option 3

 * Colorectal cancer - Wikipedia
 * Article Evaluation
 * Very full of information touching on topics such as diagnosis, pathogenesis, genetrics, and risk factors. There is a lot already in the article, although not much about COX-2 specifically. There is a small bit on how some COX-2 inhibitors can help decrease risk of colorectal cancer, but it does not go into any more details than that. Since there is so much information already, it may not be the best article to work on, as many references and paragraphs seem to be written by doctors and specialists who know much more about this topic than I do.
 * Very full of information touching on topics such as diagnosis, pathogenesis, genetrics, and risk factors. There is a lot already in the article, although not much about COX-2 specifically. There is a small bit on how some COX-2 inhibitors can help decrease risk of colorectal cancer, but it does not go into any more details than that. Since there is so much information already, it may not be the best article to work on, as many references and paragraphs seem to be written by doctors and specialists who know much more about this topic than I do.


 * Sources
 * "Colorectal Cancer Prevention (PDQ®)". National Cancer Institute. February 27, 2014. Archived from the original on July 5, 2014. Retrieved June 29, 2014. (This could be a good resource to look into if I wanted to write about how COX-2 inhibitors help decrease risk of cancer.)
 * Routine aspirin or nonsteroidal anti-inflammatory drugs for the primary prevention of colorectal cancer: recommendation statement". American Family Physician. 76 (1): 109–113. July 2007. PMID 17668849. Archived from the original on July 14, 2014. (This would be a good source for general research about how colon cancer interacts with Aspirin and the enzymes and proteins that have to do with those interactions, such as COX.)

Option 4

 * Cyclooxygenase
 * Article Evaluation
 * The main mentions of COX-2 are in the paragraph "Newer NSAIDs" because COX-2 specific inhibitors are being studied heavily now since we know the risks of inhibiting/ not inhibiting COX-1 and how it that has a more detrimental effect on the human body than if COX-2 is present or not. If I were to add to this article, I would most likely add to the "Cardiovascular side effects of COX inhibitors," because it also mentions COX-2 but is shorter and has less information whichwould make it easier to update.
 * The main mentions of COX-2 are in the paragraph "Newer NSAIDs" because COX-2 specific inhibitors are being studied heavily now since we know the risks of inhibiting/ not inhibiting COX-1 and how it that has a more detrimental effect on the human body than if COX-2 is present or not. If I were to add to this article, I would most likely add to the "Cardiovascular side effects of COX inhibitors," because it also mentions COX-2 but is shorter and has less information whichwould make it easier to update.


 * Sources
 * This article has 16 sources, many of which are research papers.
 * Wallace JL (October 2008). "Prostaglandins, NSAIDs, and gastric mucosal protection: why doesn't the stomach digest itself?". Physiological Reviews. 88 (4): 1547–65. doi:10.1152/physrev.00004.2008. PMID 18923189.Wallace JL (October 2008). "Prostaglandins, NSAIDs, and gastric mucosal protection: why doesn't the stomach digest itself?". Physiological Reviews. 88 (4): 1547–65. doi:10.1152/physrev.00004.2008. PMID 18923189. (Also runs off of the knowledge I have of COX enzymes and their interactions with NSAIDs.)

Option 5

 * Nonsteroidal anti-inflammatory drug
 * Article Evaluation
 * The first few paragraphs mention COX 1 and 2, and I could add some general things about COX-2 that are not mentioned, but since NSAIDS have to do with both cyclooxygenase enzymes, it would make sense to add some information on both of them. This page is very full of information and has a lot of contributors, so it may not be the best one to work on. It is very interesting to read through, but I think there are more qualified people to add to this article than me.
 * The first few paragraphs mention COX 1 and 2, and I could add some general things about COX-2 that are not mentioned, but since NSAIDS have to do with both cyclooxygenase enzymes, it would make sense to add some information on both of them. This page is very full of information and has a lot of contributors, so it may not be the best one to work on. It is very interesting to read through, but I think there are more qualified people to add to this article than me.


 * Sources
 * There are 145 sources sited, and a lot of research papers on NSAIDs in general and how the COX enzymes interact with them.