User:Cboursnell/Sandbox/2-oxoacid dh

This domain is found in the lipoamide acyltransferase component of the branched-chain alpha-keto acid dehydrogenase complex EC, which catalyses the overall conversion of alpha-keto acids to acyl-CoA and carbon dioxide. It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). The domain is also found in the dihydrolipoamide succinyltransferase component of the 2-oxoglutarate dehydrogenase complex EC. These proteins contain one to three copies of a lipoyl binding domain followed by the catalytic domain.