User:Cboursnell/Sandbox/3-HAO

Members of this protein family, from both bacteria and eukaryotes, are the enzyme 3-hydroxyanthranilate 3,4-dioxygenase (EC). It is part of the kynurenine pathway for the degradation of tryptophan and the biosynthesis of nicotinic acid. The prokaryotic homologue is involved in the 2-nitrobenzoate degradation pathway.

The enzyme acts on the tryptophan metabolite 3-hydroxyanthranilate and produces 2-amino-3-carboxymuconate semialdehyde, which can rearrange spontaneously to quinolinic acid and feed into nicotinamide biosynthesis, or undergo further enzymatic degradation.