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Classification
The majority of lung cancers can be characterized as either small cell lung cancer (SCLC) or non-small cell lung cancer (NSCLC). There are three major subtypes of NSCLC including squamous carcinoma, large cell carcinoma, and adenocarcinoma of the lung. Adenocarcinoma is the most common NSCLC subtype and can be further characterized. The tumor size, pattern of cell growth, and depth of cell invasion into normal lung tissue are considered in determining the final classification. The following names represent a step-wise pathologic progression in the natural course of adenocarcinoma development; Adenocarcinoma in situ (AIS), Minimally invasive adenocarcinoma (MIA), Lepidic predominant adenocarcinoma (LPA), and Invasive adenocarcinoma.

Historically, there has been much debate in the most accurate method of describing adenocarcinoma of the lung and several revisions of classification systems have been published. Most recently, the International Multidisciplinary Classification of Lung Adenocarcinoma was published in 2011 and represents the consensus of several organizations to more accurately describe this specific type of lung cancer. This current classification system aims to more reliably predict prognosis and determination of therapeutic management.

The 2011 consensus describes five subtypesbased on the type of cell that is most predominant. These subtypes are described below:


 * lepidic predominant
 * acinar predominant
 * papillary predominant
 * micropapillary predominant
 * solid predominant with mucin production

Four discrete variantsare also included in the current classification:


 * invasive mucinous adenocarcinoma
 * colloid adenocarcinoma
 * fetal adenocarcinoma
 * enteric adenocarcinoma