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Nanoparticle Mediated Histotripsy
Historoipsy, which is a mechanical cell ablation technique, is a new and innovative method can be used for cancer treatment in limited area. Using with high energy ultrasound (US) pulses, the nano size gas pocket in the cells formed by highly energic microbubbles, and removed from body in one to three weeks.

Nowadays, this promissing method is using for the cilinical cancer treatment, on the other hand, there are few limilations. One of them is needing a secondary imaging system for detecting of the cancer tissue. After that, responsible technican should focus to this area. That gives us the other limitation because some error of this procedure can cause the health cell ablation. The thirt one is ablation of limited area. On the other hand, metastasis is a highly commen and also highly dangerous situation we face on cancer patients. For the adress of these limitations, 'Nanoparticle Mediated Histotripsy' has been developed.

These new ablation technique is the combination of histotripsy and nanoparticles. Basicly, ultrasound (US) active nanoparticles were synthesized (see below), and accumulated in the cancer tissue with active targeting or the enhanced permeability and retention (EPR) effect. After the low energy US pulse application, these US active nanoparticles activated instead of gas pockets in the cells. Because the needed energy of pre-existed gas pocket is so higher compare the these US active nanoparticles. Thanks to this ability, creating more targeted and safety ablation method has been discovered.