User:Chanson36/sandbox

RLL comments
You need to do a lot more work to get this to a level appropriate for this class. Additional classification (function, number of strands, etc). You also need more references. There are ample review articles.

Structure:

A beta-propeller is an arrangement of multiple beta-sheets, each of which are made up of four anti-parallel beta-strands. The sheets are arranged vertically and each sheet takes on a slightly horizontal configuration at one end, facing out a little like the blades of a propeller. Loops between individual beta-strands come together at one end like a funnel to form an active site.

There are five classes of beta-propellers made up of 4-8 beta-sheets. The radial arrangement of these sheets forms a tunnel that narrows like a funnel and yields pseudo-symmetric axes.

Mechanism: The tunnel portion of the beta-propeller domain acts as an active site for substrates or as a place to interact with other proteins.

Folding Kinetics/Stability?: The majority of the structural stability comes from hydrophobic interactions while additional stability can come from hydrogen bonds and disulfide bond in some cases. The beta-propeller is known for its plasticity, being able to accommodate a variety of proteins in its tunnel as well as the uncommon, but natural addition or subtraction of beta-strands per sheets creating sheets with 3 and 5 strands respectively.

Function:

Involved in protein-protein interactions.

Examples: