User:Charkner/TREX Complex/Ddenoo Peer Review

General info

 * Whose work are you reviewing?

User:Charkner/TREX Complex


 * Link to draft you're reviewing
 * User:Charkner/TREX Complex


 * Link to the current version of the article (if it exists)

Evaluate the drafted changes
This article does a good job of defining the TREX complex. Through describing the separate structural component, the reader is able to understand the parts of the complex that work individually and as a unit to power biological processes such as mRNA transcription and nuclear export. Figure 1 was also a great addition to further visualize this multi-protein complex. The description of the proteins associated with the TREX complex were concise yet effective in differentiation, while providing a clear picture of their functions, binding sites, and importance to the TREX complex, as a whole.

In terms of improvement, I think it would help your argument to describe how/why the specific 4 counterparts appear in yeast, as opposed to the ones that are not. Is there an evolutionary basis/event as to why four of these subunits have counterparts in Saccharomyces cerevisiae? Additionally, it may be beneficial to add rationale as to why there is a mammalian paralog (DDX39a), despite being functionally redundant. What forms of mRNA are depleted from DDX39a vs. DDX39b? This might assist readers in understanding the role/function that mammalian DDX39a has and why it is significantly different than DDX39b.

The applications section of TREX was very insightful. Because of its conserved nature, TREX is able to induce specific immune responses, based on various mutations of the complex. I would expand on the impact of the mutations on the complex specifically. For example, what impact does deletions have on a specific subunit of the TREX complex (as opposed to a missense mutation?