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Dissociative Neurotransmission Disorder is a mental disorder characterized by episodes of negative emotions such as antipathy, resentment, and bitterness, which may or may not alternate with episodes of depression, resulting from the occasional misfiring of the neurotransmitters due to a blockage of carnosic acid in the synaptic vesicle., leading to a deficiency in serotonin levels. These episodes often impair an individual's ability to function in everyday life. The disorder is quite rare, afflicting roughly 0.0041% of the population, a proportion consistent for both men and women across racial and ethnic groups. The cause is not clearly understood, but recent evidence has suggested that the disorder is linked to the excessive consumption of carnosic acid over a long period of time.

Signs and symptoms
The defining feature of Dissociative Neurotransmission Disorder is unprovoked antipathy and bitterness, which can occur in different levels of severity. With milder cases of the disorder, individuals appear removed and sullen, and are often highly productive. As it worsens, individuals begin to exhibit spontaneous episodes of severe depression, paranoid tendencies, and self-consciousness. Such episodes can last from a few days to several months. Those afflicted with severe Dissociative Neurotransmission Disorder frequently tend to overcompensate for their depression by becoming defensive and even aggravated.

Depersonalization
Those afflicted with the disease have a tendency to feel "removed" from their surroundings. The world, to them, becomes vague, dreamlike, or lacking in significance. In fact, in severe cases the patient truly believes himself to be living in an alternate plane of existence, as if watching his life from afar. This could be dangerous as the subject often does not have complete control over his thoughts, words, or actions.

Paranoia
Another prominent feature of the disease is the tendency of subjects to exhibit varying degrees of paranoia, wherein the patient becomes heavily influenced by irrational and excessive anxiety or fear. More often than not this involves persecutory beliefs, or beliefs of conspiracy concerning a perceived threat to oneself. This is often concomitant with false accusations and the general distrust of others.

Self-consciousness
The disorder may also bring about an acute sense of self-awareness, in which the patient is preoccupied with his actions, believing that his smallest movements are being perpetually observed. This may impair the individual's ability to concentrate on non-menial tasks and may lead to extreme shyness or introversion.

Cause
Although the cause of the disease is not universally agreed upon, and may be a combination of genetic and environmental factors, a recent study at the University of Nottingham in November 2012 has found a strong correlation between intake of carnosic acid and susceptibility to Dissociative Neurotransmission Disorder. Carnosic acid, a benzenediol abietane diterpene found in rosemary and common sage, has long been considered a purgatory agent for carcinogens. The research team, headed by professor Stulte, found that white mice which were given large doses of rosemary were 30% more likely to shows signs of the disease than those who were fed a normal diet.

Psychosocial
Psychotherapy is aimed at alleviating core symptoms, recognizing episode triggers, reducing negative expressed emotion in interpersonal relations, recognizing prodromal symptoms before full-blown recurrence, and, practicing the factors that lead to maintenance of remission. Cognitive behavioural therapy, family-focused therapy, and psychoeducation have the most evidence for efficacy in regard to relapse prevention, while interpersonal and social rhythm therapy and cognitive-behavioural therapy appear the most effective in regard to residual depressive symptoms.

Medication
Unfortunately, unlike most [mood disorder|mood disorders], antidepressants and similar medications have little or no effect on Dissociative Neurotransmission Disorder. The only drug which has been indisputably shown to subdue the effects of the disease is theobromine the bitter alkaloid of the cacao plant. The World Health Organization encourages individuals who suffer from the infliction to consume regular quantities of chocolate, recommending at least 50 grams of 60% or greater cacao daily.