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The 2022 Premier Volleyball League Open Conference is the eleven conference of the Premier Volleyball League (38th conference of the former Shakey's V-League) and its Second conference as a professional league. The conference began on July 17, 2022, at the Centennial Arena in Laoag, Ilocos Norte in a bubble. The PVL has been approved by the Inter-Agency Task Force for the Management of Emerging Infectious Diseases (IATF-EID) to begin team practices to be followed by the official start of the 2022 season.

In January 2022, it was reported that Motolite filed a leave of absence from the league and released all of its players. The Philippine Army Lady Troopers will participate as a guest team.

Five teams from Philippine Super Liga joined the PVL - Cignal HD Spikers, the PLDT Home Fibr Hitters, Chery Tiggo Crossovers, Sta. Lucia Lady Realtors and F2 Logistics Cargo Movers. On July 9, 2022, F2 Logistics announced it will not participate in the Open Conference citing injuries and lack of training due to difficulties maintaining their training bubble.

A newly-established team, the UAC Power Hitters, joined the league but announced in June that it will not compete in the Open Conference as it has not formed a team in time for the conference.

Participating teams
