User:Christian Sell

Christian Sell

Biomedical Research Scientist Drexel University College of Medicine Philadelphia, PA

Interests:

Aging Senescence Mitochondria Autophagy Signal transduction

Publications:

Janakidevi K, Murray C, Sell C, Held P. Fluorometric analysis of DNA in cell cultures. Anal Biochem. 1987:172;7881.

Held P, Murray C, Sell C, Janakidevi K. Limited attachment as a method to synchronize cells grown in monolayer culture. In Vitro Cell Dev Biol. 1989:25;10251029.

Sell C, Held P, Murray C, Janakidevi K. Treatment of porcine aortic smooth muscle cells with phorbol esters prevents nodulation in vitro. Cell Biol Int Rep. 1992:16;221232.

Travali S, Ferber A, Reiss K, Sell C, Koniecki J, Calabretta B, Baserga R. Effect of the myb gene product on expression of the PCNA gene in fibroblasts. Oncogene. 1991:6;887894.

Sell C, Chen H-M, Baserga R. A simple method for the generation of single stranded probes for run-on transcription assays. Biotechinques. 1992:12;692694.

Sell C, Chang C-D, Koniecki J, Chen HM, Baserga R. A cryptopromoter is activated in the PCNA gene of growth-arrested cells. J Cell Physiol. 1992:152;177184.

Reiss K, Porcu P, Sell C, Baserga R. The role of the IGF-I receptor in the proliferation of hemopoietic cells. Oncogene. 1992:6;887894.

Pietrzkowski Z, Sell C, Lammers R, Ulrich A, Baserga R. The role of insulin-like growth factor 1 (IGF-I) and the IGF-I receptor in epidermal growth factor (EGF) stimulated growth of 3T3 cells. Mol Cell Biol. 1992:12;38833889.

Surmacz E, Reiss K, Sell C, Baserga R. Cyclin D-1 mRNA is inducible by PDGF in cultured fibroblasts. Cancer Res. 1992:52;45222525.

Sell C, Ptasznik A, Chang C, Swantek J, Cristofalo VJ, Basrega R. IGF-I receptor levels and the proliferation of young and senescent human fibroblasts. BBRC. 1993:194;259265.

Ferber A, Chang C, Sell C, Ptaznik A, Cristofalo VJ, Hubbard-Smith K, Ozer H, Adamo M, Roberts C, LeRoith D, Baserga R. Failure of senescent human fibroblasts to express the IGF-I gene. J Biol Chem. 1993:268;1788317888.

Baserga R, Porcu P, Sell C. Oncogenes, growth factors, and control of the cell cycle. Cancer Surveys 1993:16;201213.

Resnicoff M, Sell C, Ambrose D, Baserga R, Rubin R. Ethanol inhibits the autophosphorylation of the insulin-like growth factor 1 (IGF-I) receptor and the IGF-I mediated proliferation of 3T3 cells. J Biol Chem. 1993:268;2177721782.

Sell C, Rubini M, Rubin R, Liu J, Efstradiadis A, Baserga R. Simian virus 40 tumor antigen is unable to transform mouse embryonic fibroblasts lacking the insulin-like growth factor (IGF) type 1 receptor. Proc Natl Acad Sci. 1993:90;1121711221.

Sell C, Dumenil G, Devaud C, Miura M, DeAngelis T, Efstradiadis A, Baserga R. Growth of mouse embryo cell lines with a targeted disruption of the insulin-like growth factor 1 (IGF-I) receptor genes. Mol Cell Biol. 1994:14;36043612.

Ambrose D, Resnikoff M, Coppola D, Sell C, Miura M, Jameson S, Baserga R, Rubin R. Growth regulation of human glioblastoma T98G cells by insulin-like growth factor 1. J Cell Physiol. 1994:159;92100.

Resnicoff M, Sell C, Rubini M, Coppola D, Ambrose D, Baserga R, Rubin R. Rat glioblastoma cells expressing an antisense RNA to the insulin-like growth factor 1 (IGF-1) receptor are nontumorigenic and induce regression of wild type tumors. Cancer Res. 1994:54;22182222.

Coppola D, Ferber A, Miura M, Sell C, D'Ambrosio C, Rubin R, Baserga R. A functional insulin-like growth factor 1 receptor is required for the mitogenic and transforming activities of the epidermal growth factor receptor. Mol Cell Biol. 1994:14;45884595.

Resnikoff M, Coppola D, Sell C, Rubin R, Ferrone S, Baserga R. Growth inhibition of human melanoma cells in nude mice by antisense strategies to the insulin-like growth factor receptor. Cancer Res. 1994:54;48484850.

Sell C, Baserga R, Rubin R. Insulin-like growth factor 1 (IGF-1) and the IGF-1 receptor prevent etoposide-induced apoptosis. Cancer Res. 1995:55;303306.

Surmacz E, Sell C, Kato H, Roberts CT, LeRoith D, Baserga R. Dissociation of mitogenesis and transforming activity by C-terminal truncation of the insulin-like growth factor 1 receptor. Exp Cell Res. 1995:218;370380.

Xu S, Sell C, DuBois GC, Baserga R. A novel growth stimulating activity from BRL-3A cell conditioned medium. Cell Prolif. 1997:30;295307.

Hoff H, Tresini M, Li S, Sell C. DBI-1, a novel notch related gene, is regulated by insulin-like growth factor 1. Exp Cell Res. 1998:328;359370.

Tresini M, Mawal-Dewan M, Cristofalo VJ, Sell C. A phosphatidylinositol 3-kinase inhibitor induces a senescent-like growth arrest in human diploid fibroblast cells. Cancer Res. 1998:58;14.

Li S, Mawal-Dewn M, Cristofalo VJ, Sell C. Enhanced proliferation of human fibroblasts in the presence of dexamethasone is accompanied by changes in p21Waf 1/Cip 1/Sdi 1 and the IGF-1 receptor. J Cell Physiol. 1998;177:396401.

Li S, Hoff H, Zhang H, Sell C. Activation of the insulin-like growth factor type 1 receptor by deletion of amino acids 870-905. Exp Cell Res. 1998:243;326333.

Coljee VW, Rottenberg M, Tresini M, Cristofalo VJ, Francis MK, Sell C. The regulation of EPC1/PEDF in normal human fibroblasts is posttranscriptional. J Cell Biochem. 2000:79;442452.

Zhang H, Hoff H, Sell C. Insulin-like growth factor I mediated degradation of insulin receptor substrate 1 is inhibited by epidermal growth factor in prostate epithelial cells. J Biol Chem. 2000:275;225582256.

Zhang H, Hoff H, Marinucci T, Cristofalo VJ, Sell C. Mitogen independent phosphorylation of S6K1 and decreased ribosomal S6 phosporylation in senescent human fibroblast cells. Exp Cell Res. 2000:259;284292.

Mawal-Dewan M, Lorenzini A, Frisoni L, Zhang H, Cristofalo VJ, Sell C. Regulation of collagenase expression during replicative senescence by Akt-forkhead signaling. J Biol Chem. 2002:277;78577864.

Wieland I, Ropke A, Stumm M, Sell C, Wiedle U, Wieacker P. Molecular characterization of the DICE1 (DDX26) tumor suppressor gene in lung carcinoma cells. Oncol Res. 2002:12;491500.

Mawal-Dewan M, Frisoni L, Cristofalo VJ, Sell C. Extension of replicative lifespan in WI-38 human fibroblasts is accompanied by suppression of p21Waf1/Cip1/Sdi1 levels. Exp Cell Res. 2003:285;9198.

Zhang H, Hoff H, Sell C. Downregulation of IRS-1 protein in thapsigargin treated human prostate epithelial cells. Exp Cell Res. 2003:289;352358.

Wieland I, Sell C, Weidel UH, Wieacker P. Ectopic expression of DICE1 suppresses tumor cell growth. Oncol Rep 2004;12:207-11.

Stearns M, Tran J, Zhang H, Francis MK, Sell C. Activated Ras enhances insulin-like growth factor 1 mediated induction of vascular endothelial growth factor in prostate epithelial cells. Cancer Res 2005;65:2085-8.

Sell C, Francis MK, Mullin J. Ras mutations selectively alter tight junction permeability. Mol Cell Biol 2005;16:5538-50.

Hayes CS, DeFeo K, Lan L, Paul B, Sell C, Gilmour SK. Elevated levels of ornithine decarboxylase cooperate with Raf/ERK activation to convert normal keratinocytes into invasive malignant cells. Oncogene 2006 Mar 9;25(10):1543-53.

Garcia F, Urvanska K, Koltowski L, Reiss K, Sell C. Seminal vesicle production of IGF-I provides an initiating signal for intraepithelial basal cell hyperplasia in the prostate. Clin Can Res 2007: 13:3140-43

Crowe E, Thomas J, Johannes G, Sell C, Torres T. Activation of the 20S proteasome may enhance clearance of oxidized proteins in the brain. Mech Ageing Dev. 2009 Nov-Dec;130:793-800

Lorenzini A., Johnson B., Oliver A., Tresini M., Austad S., Sell C., Cristofalo VJ., Stamato T. Significant Correlation of Species Longevity with DNA Double Strand Break-Recognition but not with Telomere Length. Mech Aging Dev 2009;30:784-92

Filleur S, Hirsch J, Wille A, Schön M, Sell C, Shearer MH, Nelius T, Wieland I. INTS6/DICE1 inhibits growth of human androgen-independent prostate cancer cells by altering the cell cycle profile and Wnt signaling. Cancer Cell Int. 2009 Nov 11;9:28.

Crowe, E, Sell C, Thomas J, Johannes G, Torres C. Activation of proteasome by IGF-1 may enhance clearance of oxidized proteins in the brain. Mech Aging Dev 2009;130:793.

Fink L, Lerner C, Torres P, Sell C. Ku80 is essential for growth in normal human fibroblasts. Cell Cycle 2010; 18:3798-806.

Bitto A, Sell C, Crowe L, Lorenzini A, Malaguti M, Torres C. Senescence of human astrocytes. Exp Cell Res 2010;316:2961.

Bitto A, Lerner C, Torres C, Perres V, Lorenzini A, Malaguti M, Roell M, Hrelia S, Ikeno Y, Matzko ME, McCarter R, Sell C. Long-Term IGF-I Exposure Decreases Autophagy and Negatively Impacts Cell Viability. PLOS ONE 2010;5(9):e12592.

Stearns ME, Amatangelo MD, Varma D, Sell C, Goodyear SM. Combination therapy with epigallocatechin-3-gallate and doxorubicin in human prostate tumor modeling studies: inhibition of metastatic tumor growth in severe combined immunodeficiency mice. Am J Pathol. 2010;177:3169-79.

Hammers DW, Matheny RW Jr, Sell C, Adamo ML,Walters TJ, Farrar RP. Impairment of IGF-I expression and anabolic signaling following ischemia/reperfusion in skeletal muscle of old mice. Exp Gerontol 2011;46: 265-269.

Sell C. Ku circles the telomere? Aging (Albany) 2011; 3:329-invited editorial.

Lorenzini A, Fink LS, Stamato T, Torres C, Sell C. Relationship of spindle assembly checkpoint fidelity to species body mass, lifespan, and developmental rate. Aging (Albany) 2011; 3: 1206-12.

Lorenzini A, Stamato T, Sell C. The disposable soma theory revisited: time as a resource in the theories of aging. Cell Cycle 2011; 10:3853-8.

Fink LS, Roell M, Caiazza E, Lerner C, Stamato T, Hrelia S, Lorenzini A, Sell C. 53BP1 contributes to a robust genomic stability in human fibroblasts. Aging 2011;3:236-45.

Bhat R, Crowe L, Bitto A, Johnson B, Trojanowski J, Katsetos C, Sell C, Torres C. Astrocyte Senescence as a Component of Alzheimer's Disease. PLOS ONE 2012;7(9):e45069.

Guidelines for the use and interpretation of assays for monitoring autophagy DJ Klionsky, FC Abdalla, H Abeliovich, RT Abraham, A Acevedo-Arozena, K. et al. Autophagy 8 (4), 445-544

Pirrone V, Libon DJ, Sell C, Lerner CA, Nonnemacher MR, Wigdahl B. Impact of age on markers of HIV-1 disease. Future Virol. 2013 ;8(1):81-101.

Lerner C, Bitto A, Torres C, Pulliam D, Konigsberg M, Van Remmen H, Torres C, Sell C. The mammalian retrograde response: p62/SQSTM1 turnover mediates expression in nuclear and mitochondrial genomes. Aging Cell, In Press

Salmon AB, keno Y, McCarter R, Sell C. Mice hypomorphic for the Igf1 allele are resistant to weight gain induced by high fat diet. 2013 (Submitted).

Lorenzini A, Salmon A, Lerner C, Torres C, Ikeno Y, Motch S, McCarter R, Sell C. Mice Producing Reduced Levels of Insulin-Like Growth Factor Type 1 Display an Increase in Maximum, but not Mean, Lifespan. J Gerontology, In Press

Eskin B, Tank J, Montgomery O, Sell C. Estrogens and IGF-1 correlations during menopause and aging. (In Preparation).

Invited Reviews: Sell C. Caloric restriction and insulin-like growth factors in aging and cancer. Horm Metab Res. 2003:35;705-711. *

Bitto A, Lerner CA, Nacarelli T, Torres T, Sell C. p62/SQSTM1 at the interface of aging, autophagy, and disease. 2013 AGE In Press

Book Chapters: Baserga R, Porcu P, Rubini M, Sell C. Cell cycle control by the IGF-1 receptor. In: Current Directions in Insulin like growth factor research. LeRoith D, Raizada M K, eds. Advances in Experimental Medicine and Biology. Vol 343. New York NY: Plenum Press; 1993:105-112.

Hoff H, Zhang H, Sell C. Proteasome-mediated degradation during the cell cycle. In: Methods in Molecular Biology; Totowa, NJ: Humana Press; 2004;285:95-104.

Hoff H, Zhang H, Sell C. Cellular transformation. In: Methods in Molecular Biology Series. Totowa, NJ: Humana Press; 2004;285:79-92.

Books: Lifespan Extension: Single-cell Organisms to Man Humana Press, C. Sell, H. Brown-Borg, A. Lorenzini ed,. 2009