User:ChristinaBaze/sandbox

What is this? Isn't your topic "Epigenetics used as an antiviral agent"? and aren't you working with Alec on this? In what sense is this an outline? OK, I think I see that this is just a previous homework in the wrong place. Delete it.

*** This is not our draft, I am just using my sandbox to put together a coherent chunk to transfer all at once to Alec's sandbox***

Viral Epigenetic Mechanisms

Epigenetic regulation of viruses is likely a result of the evolutionary arms race in which a cellular host attempts to silence viral DNA, such as through chromatin remodeling. However, some viruses have evolved to twist this process to their own advantage by establishing latency. Latent proviral DNA exists as heterochromatin in the host nucleus, evading cellular defenses. Five epigenetic processes have been described: DNA methylation, nucleosome positioning, histone variants, histone modifications, and regulatory RNA. Here these mechanisms for viral chromatin remodeling and gene silencing will be breifly described.

DNA methylation

Nucleosome positioning and chromatin assembly

Histone variants

Histone modification

Regulatory RNA

Maintenance of Latency

Use Lieberman for this; episome maintenance factors, genome integration, Polycomb repression, non-coding RNA

Reactivation

HSV: de novo translation of VP16 --> genome-wide derepression