User:ClosingtheGap/Omnigenic model/Jjherlan Peer Review

General info

 * Whose work are you reviewing?

ClosingtheGap


 * Link to draft you're reviewing
 * https://en.wikipedia.org/wiki/User:ClosingtheGap/Omnigenic_model?veaction=edit&preload=Template:Dashboard.wikiedu.org_draft_template
 * Link to the current version of the article (if it exists)
 * Omnigenic model

Evaluate the drafted changes
(Compose a detailed peer review here, considering each of the key aspects listed above if it is relevant. Consider the guiding questions, and check out the examples of what feedback looks like.)

Synopsis

The article provides a concise introduction and description of the Omnigenic model, but could be strengthened by specific examples in the Evidence section. For example, the article could provide more information form a primary source, such as reference #4, Liu et al. (2019).

Introduction

The article could be strengthened by more specific examples of the model organisms applied to the Omnigenic Model. For example, the author could state an example in the introduction after the statement of how the Omnigenic Model affects the heritability of complex traits in the introduction. In general, the author describes the theory of the theory of the Omnigenic Model well, but needs to include more examples of applications of the theory to practice or methods. Lastly, the relation of the Omnigenic Model to GWAS and complex traits of diseases is very compelling but falls short of comprehension without examples of application, i.e., specific descriptions of the types of diseases described in the primary literature.

History

Paragraph 1: Clear definition of the Polygenic Model and its relation to the Omnigenic Model is well described.

Paragraph 2: This article clearly defines the functions of core and peripheral genes. The article could be strengthened with a comparison between the Omnigenic Model and the Infinitesimal Model

Evidence Paragraph 1: The terms, or phrases, cell-specific disease pathways and regulatory pathways could be more clearly defined.

Paragraph 2: To strengthen the concluding paragraph and emphasize the importance of trans-regulatory elements, the article could include an example, or evidence, of trans-regulatory elements affecting heritability.

Technical edits

Line 2: Change effect to affect

Line 5: Change Fischer to Fisher