User:Cmasl1/sandbox

Article Evaluation
Tau protein

1.) Most of the information is relevant as it describes what a Tau protein is and what it does. Part of the information mentions where it could be located and how it can lead to diseases such as Alzheimer's or Parkinson's. This page does a good job explaining the function and structure keeping it relevant to the page.

2.) This article appears to be neutral as I cannot tell where it could be biased in anyway. The information seems to be straightforward facts that cannot really be disputed.

3.) There seems to be a lot of information concerning function, structure, and genetics compared to sections that relate to brain injuries and Alzheimer's disease. This is an issue because it is important to know how to apply that information to real life issues like Alzheimer's or brain injuries.

4.) From reading some of the references, I've been able to conclude that the information on the Tau Protein page is closely correlated and well said compared to its sources. The sources I clicked on worked and all had relevance toward the subject.

5.)The facts provided all had sources that were reliable and scientific enough to talk about such a complicated protein. These sources did not seem to be biased in any way due to the fact they were not opinion related articles. These were articles and books that stated complex facts to help others learn about the Tau protein.

Article Additions
Tau Protein

1.) Within the Clinical significance section on the Tau protein page, I plan on adding specific information concerning the effects Tau has on a living cell. I would then explain how Tau helps degrade the cell leading to symptoms of Alzheimer's disease. https://www.alz.org/braintour/tangles.asp
 * Tau protein has a direct effect on the breakdown of a living cell caused by tangles that form and block nerve synapses. Tangles are clumps of Tau protein that stick together and block essential nutrients that need to be distributed to cells in the brain, causing the cells to die.
 * The Alzheimer's Association explains how the Tau protein clumps together which then creates tangles in a cell. This causes cells to break down and die due to a lack of nutrients.

2.) My second addition is going to conclude research that has been done to find medication that destructs Tau within the brain. https://www.alz.org/research/science/alzheimers_treatment_horizon.asp
 * Vaccines have been found that attack the Tau protein which targets tangles, one of the leading causes of Alzheimer's. This would reduce symptoms for those with Alzheimer's disease and could eventually lead to a cure.
 * The Alzheimer's Association mentions research that has been done on vaccines that would attack the Tau protein and break it down. This would clear tangles out of cells and lower symptoms of Alzheimer's disease.

3.) My third comment is going to suggest that concussions could possibly lead to an increase in Alzheimer's disease for future generations due to the Tau protein. https://www.webmd.com/alzheimers/news/20170112/link-seen-between-concussions-and-alzheimers
 * Concussions increase the speed of cognitive decline which is caused by a degradation in the brain from Tau protein.
 * Healthday Reporter Robert Preidt wrote about new discoveries explaining how concussions accelerate the pace of degradation within the brain of an oncoming Alzheimer's patient. This causes an increase in cognitive decline which is a worsening symptom of the disease.

Final Edits
Tau Protein


 * Tau protein has a direct effect on the breakdown of a living cell caused by tangles that form and block nerve synapses. Tangles are clumps of Tau protein that stick together and block essential nutrients that need to be distributed to cells in the brain, causing the cells to die.
 * Vaccines have been found that attack the Tau protein which targets tangles, one of the leading causes of Alzheimer's. This would reduce symptoms for those with Alzheimer's disease and could eventually lead to a cure.
 * Concussions increase the speed of cognitive decline which is caused by a degradation in the brain from Tau protein.