User:CoffeeShopFantasy/Mycoplasma genitalium

'''Figure 1: Mycoplasma Genitalium has a flask-shaped structure that aids in the ability for host cell membrane entry. The organelle is composed of the main components: the terminal button, rod, and wheel. The narrow end of the organelle is composed of many cytoskeleton proteins which aids in the cell structure. MSR (methionine sulphoxide reductase (Msr), organic hydroperoxide reductase (Ohr), OsmC (osmotically inducible protein C) and other related structures are involved in antibiotic resistance. NAPs (P140 and P110) are transmembrane dimers that can be in an open or closed conformation that can change structure. P140 and P110 are two major adhesins and are identified as virulence factors. GADPH and PDH are mucin binding proteins/adhesins. Proteins in the wheel are known as accessory proteins which aid in translocation and positioning of P140 and P110. Mycoplasma Genitalium activates inflammatory responses in host through the membrane lipoproteins. The MIB-MIP system are important factors in evading the host immune system. Nuclease is a toxic enzyme.''' Mycoplasma genitalium uses gliding motility, adhesion, and intracellular invasion using the tip organelle to enhance the organism's pathogenicity. The tip organelle is made of three parts; the terminal button, segmented pair plates, and a wheel complex. As drug resistance increase, molecular testing should be done to test for antimicrobial resistance before starting treatment. Mgen was the first bacteria to be fully sequenced. Mgen evolved from a gram-positive ancestor that was clostridium-like but has lost the genes to code for the enzymes involved in de novo nucleic acid synthesis, amino acid synthesis, and synthesis of fatty acids. This means that Mgen needs the host's growth factors to keep reproducing. Although Mgen has abilities that help it adhere to cells, it is still unknown how the bacteria can maintain an infection inside the epithelial cells of the ectocervix and vagina when shedding of the apical layer of cells occur. The organism's ability to have adhesion to host cells relies of two proteins, P110 and P140. Adhesion is an important step in beginning an infection in a cell and Mgen can adhere to spermatozoa, erythrocytes, and epithelial cells. The terminal organelle relies on these proteins as well because without them the organelle was not present. The segmented pair plates of Mgen is a core of dense electrons which is anchored to the cell membrane. The end of this core is in contact with the wheel complex and the wheel complex contains the proteins MG219, MG200, MG386, and MG491 which aid in the gliding motility of the bacteria. Although Mgen lacks secreted virulence factors, the protein MG186 degrades host nucleic acids due to it being a calcium-dependent membrane-associated nuclease.

plans:

Fix photo ? photo of genome vs photo of bacterium

Add links to notable things in the page (ex: link "humans" to humans wikipedia page)

How many genes are there?? 525 482 or 475???

Edited naming of bacterium according to Gupta et al. on October 22nd

Un-do renaming of Mycoplasma Genitalium on November 11th

https://www.microbiologyresearch.org/content/journal/ijsem/10.1099/ijsem.0.003632 Suggests that the name is, in fact Mycoplasma, and not Mycoplasmoides. Dangit.

Sweeping changes made immediately.

Insert explanation of the naming confusion in History:

Some researchers push for a change of the name of Mycoplasma Genitalium to Mycoplasmoides Genitalium. This naming is counter to the general consensus in the field, and is mostly rejected. The re-naming violates essential points of the International Code of Nomenclature of Prokaryotes.

November 24th


 * Signs and Symptoms → Symptoms of Infection

Disease names/symptoms repeated in multiple sections, combined them into a single section


 * Rephrasing for Clarity

Combined and rephrased sentences for better flow, but retained original main points and source contents