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=CIROP Overview= CIROP is a highly conserved gene involved in the function of the left-right organizer in embryo development.

Gene
The CIROP gene is found in humans on the negative strand of the long arm of chromosome 14 at position 11.2. CIROP is 5,928 bp It has no tissue specificity with low expression overall and it is most expressed in the testis, thyroid, and lungs.

Transcript
There are two transcript isoforms for CIROP the first being 2,656 base pairs long with 16 exons. while isoform 2 is 2,366 base pairs long with 14 exons.

Protein
The most complete sequence produces a protein that is 788 amino acids long. The protein features 5 glycosylation sites, 2 disorganized regions, and a transmembrane protein.

Function
CIROP is a recessive gene and mutations can cause developmental issues consistent with the disorder heterotaxy.

evolutionary History
CIROP first appeared in lampreys approximately 563 million years ago. CIROP is in the peptidase M8 family which has 14 constituents. CIROP is evolving quickly at a comparable rate to the fibrinogen alpha chain, as shown in figure 2. CIROP has orthologs in most mammals, amphibians, lungfish, and lampreys. It is not found in swine and most whales. .

