User:Cora Christine/CTDNEP1

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In cell biology, CTDNEP1 is a protein coding gene involved in neural development. It is a member of DXDX(T/V) phosphatase family and is a potential regulator of neural tube development in Xenopus. The gene promotes neural development by inhibiting Bone Morphogenetic Proteins (BMPs). CTDNEP1 stands for CTD nuclear envelope phosphatase 1, previously known as the Dullard protein. This gene is relatively small and only contains 244 amino acids.

Description
CTDNEP1 stands for CTD nuclear envelope phosphatase 1. It is a protein coding gene, which include phosphatase activity and protein serine/threonine phosphatase activity. This gene is relatively small and only contains 244 amino acids. CTDNEP1 encodes a protein serine/threonine phosphatase and dephosphoroylates LPIN1 and LPIN2. LPIN1 and LPIN2 catalyze the reaction of the conversion of phosphatidic acid to diacylglycerol. The reaction can affect and change the lipid concentration of the endoplasmic reticulum and the nucleus.

CTDNEP1 and BNP signaling
Neural development happens in the dorsal ectoderm. In the genus Xenopus, over expression of CTDNEP1 undergoes apoptosis in early development. CTDNEP1 helps promote Ubiquitin by proteosomal degradation. CTDNEP1 mRNA is derived from maternal genes and is localized within the animal neural hemisphere. Functioning negatively for the regulation of Bone Morphogenetic Proteins (BMPs), CTDNEP1 conserves the C-terminal region of NLI-IF, in which is fairly dominant in cellular functions. CTDNEP1 is essential for inhibiting BMP receptor activation during Xenopus neuralization.

Human CTDNEP1
Human CTDNEP1 has shown that the protein has two membrane spanning regions. One end is the N-terminal end, which helps localize the protein to the nuclear envelope. CTDNEP1 dephosphorylates the mammalian phospatidic acid phosphatase, lipin. CTDNEP1 participates in a unique phosphatase cascade regulating nuclear membrane biogenesis, and that this cascade is conserved from yeast to mammals. There is belief that CTDNEP1 may have other targets that is not only associated with the nuclear envelope. In recent studies, CTDNEP1 interacts with BMP type 1 to inhibit dependent phosphorylation. This can conclude that it is a potential source for regulating the level of BMP signaling and can affect germ cell specification.

This article has been modified from the original Dullard protein page.