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Electrophysiological recordings from brain slices are a direct way to probe neural function, detect pathological functional abnormalities and explore the sensitivity of spontaneous and evoked electrical signal transmissions to drugs.

The recordings are a valuable tool in the study of synaptic plasticity, which is thought to underlie learning, memory and brain pathologies. Up-regulation or down-regulation of synaptic transmissions can give insight on cellular and network mechanisms of numerous central nervous system diseases, including Alzheimer’s disease, autism and ataxia.

Neuronal electrophysiology (ephys) is the study of the electrical properties of biological cells and tissues in the nervous system. Changes in these properties allow the nervous system to perform its important functions. These are not only responsible for keeping us alive, but also responsible for allowing us to achieve higher levels of consciousness.

Multi-electrode arrays (MEAs) or microelectrode arrays are devices that contain multiple plates or shanks through which neural signals are obtained or delivered, essentially serving as neural interfaces that connect neurons to electronic circuitry. Multi-electrode arrays (MEAs) are ideal for neural studies, as they are easily multiplexed, allowing for multiple, concurrent experiments. The variety of MEA biochips allows one to customize electrophysiological recordings and gather data, from single neurons to large groups of cells.

https://www.scientifica.uk.com/neurowire/neuronal-electrophysiology-the-study-of-excitable-cells

https://www.criver.com/products-services/discovery-services/vivo-pharmacology/neuroscience-translational-tools/electrophysiology/brain-slice-electrophysiology?region=3601

https://www.researchgate.net/topic/Multielectrode-Arrays

Neuronal electrophysiology

In reference to the brain, there are two main ways of recording neuronal evidence from neuronal electrophysiology. Due to membrane depolarization and a consistently positive charge, intracellular recordings are considered to have a millivolt amplitude. Extracellular recordings waver in electrical potential and the amplitude is in microvolt. These cellular recordings of electrical neuronal activity can be measured by either a magnetoencephalography or electroencephalogram.

Biological cells and tissues in the nervous system can be studied by their electrical properties using neuronal electrophysiology. Our nervous systems perform their functions as a result of the changes in those cells and tissues. These changes also allow us to expand our consciousnesses as well as keeping us alive. Electrical signal transmissions' response to drugs can be evoked by electrophysiological recordings from brain slices. These recordings can also explore, detect and probe different sensitivities, neural functions and abnormalities in the brain. Synaptic plasticity, changes at synapses, can be studied using electrophysiological recordings. Brain pathologies, memory and learning are a few examples of what can be affected by synaptic plasticity. Alzheimer's disease, autism and ataxia are some examples of central nervous system diseases that can be further explored by studying the regulation of synaptic transmissions. Multi-electrode arrays are multi-purpose and are the main choice for neural research. Multi-electrode arrays, also called microelectrodes, are devices that transmit neural signals. These devices can have multiple experiments performed with them due to the fact that they're multiplexed. Electrophysiological recordings, with MEA help, can not only gather data from groups of cells, but also from single neurons.

Neuronal electrophysiology is the study of electrical properties of biological cells and tissues within the nervous system. With neuronal electrophysiology doctors and specialists can determine how neuronal disorders happen, by looking at the individual's brain activity, such as which portions of the brain light up during any situations encountered.

EEG’s or Electroencephalography includes scanned pictures of the brain. The electrical pulses that help within this procedure are the pulses that record the brain activity.

According to the article “Brain Electrophysiology” from the ScienceDirect website by authors Paul J. Eslinger, Freeman M. Chakara, et. al., when it comes to alcohol and other drugs, electrophysiology has become a big help by determining how alcohol can affect the brain in a minor and major way. Even when we are asleep, certain parts of our brain are active while the other areas are not as active, because the brain doesn’t shut down completely while we are asleep. The brain is the most important organ besides the heart that keeps us alive.

https://www.scientifica.uk.com/neurowire/neuronal-electrophysiology-the-study-of-excitable-cells

https://www.sciencedirect.com/topics/medicine-and-dentistry/brain-electrophysiology