User:Courtney Pinard/Sonic hedgehog

Article Improvement/Addition ideas
This article needs to have the introductory information about what sonic hedgehog is in the beginning paragraph of the article as to properly prepare the reader for the detailed applications to follow. For example, some of the information in the "Function" section of the article such as "The SHH gene is a member of the hedgehog gene family with five variations of DNA sequence alterations or splice variants. SHH is located on chromosome seven and initiates the production of Sonic Hedgehog protein." should probably be edited and moved to the beginning section. Then, after introducing what Sonic Hedgehog is the article can move into the information about how this protein was discovered. Currently, the article discusses the Nobel Prize winning research behind the discovery of the protein, but I feel like the article can be a bit more thorough with the information regarding the research methods and significance of the hedgehog signaling pathway. This section could also use a basic graphic to better describe the hedgehog signaling pathway. More information towards and explanation behind the inclusion of Robotnikinin in the final section of this page is needed. I don't think that the naming of the morphogen is very significant for this page and shouldn't require two separate sections.

'''This is very ambitious because it is a well developed article. Not necessarily a barrier but it requires a very caring touch.'''

You were supposed to suggest two possible edits or one new article "Wiki 4 Propose two Wikipedia editing topics or the idea for a New Wikipedia article."

'''The major problem is that you do not discuss SHH in the context of epigenetics. You have not made a connection. See of you can fix these and let me know with a Canvas email when the sandbox has been updated. It has to be an article about epigenetics. -- Dr. Atkinson'''

Basic outline proposal for the page:


 * Intro
 * Discovery
 * Nobel Prize experiment
 * Positional Signaling Model/Limb bud experiment
 * Notochord experiments
 * Overview of Hedgehog morphogen family
 * Key hedgehogs
 * Main signaling cascade
 * Hedgehog receptors
 * Other significant morphogens
 * Function of Sonic hedgehog
 * Signaling molecule mechanism
 * Axon guidance
 * Pleiotropy of Hedgehog defects
 * Functions outside of the central nervous system
 * Continued research on Sonic hedgehog
 * Clinical significance of understanding manipulations within hedgehog signaling cascade