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Caffeine is one of the most commonly used substances in the world. With 82-92% of adults worldwide using it, [1 ], it is no wonder that we see caffeine and anxiety issues linked together. Numerous studies have been conducted to show this relationship. One in particular was conducted by a program called Neuropsychopharmacology. This team showed relationship between A2a Receptor Gene Polymorphisms and Caffeine-Induced Anxiety. Click on thelink to learn more about this study.