User:Cplamm15/Prostaglandin E2 receptor

Prostaglandin E2 and its effect on inflammation

Prostaglandins are derived from the parent molecule arachidonic acid. The synthesis of prostaglandins can be blocked by anti-inflammatory drugs such as ibuprofen. Anti-inflammatory drugs block the synthesis of cyclooxygenases which in turn produce prostaglandins. Prostaglandins (PG) are the result of an enzyme cascade pathway that includes the enzymes cyclooxygenases and PG synthases. Prostaglandin E2 is produced by PGE synthase and via the activation of EP1-4 receptors. Prostaglandin E2s (PGEs) are associated with the development of vascular diseases that lead to inflammation in the body. In the human body, PGEs are involved in the control of the vascular smooth muscle, cell migration and the division of a cell into two daughter cells. The process of producing two daughter cells via division is called cell proliferation.