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Membrane steroid receptors (mSRs), also called extranuclear steroid receptors, are a class of cell surface receptors activated by endogenous steroids. that bind and are and mediate rapid, non-genomic signaling via modulation of intracellular signaling cascades.

Steroid hormone receptors can produce slow genomic responses or the rapid, non-genomic response in the case of mSRs. They are another means besides classical nuclear steroid hormone receptors for steroids mediate their biological effects.

Known groups of mSRs include:


 * Membrane sex steroid receptors
 * Membrane estrogen receptors (mERs) – e.g., GPER, ER-X, Gq-mER
 * Membrane progesterone receptors (mPRs) – mPRα, mPRβ, mPRγ, mPRδ
 * Membrane androgen receptors (mARs) – GPRC6A, ZIP9
 * Membrane corticosteroid receptors
 * Membrane glucocorticoid receptors (mGRs)
 * Membrane mineralocorticoid receptors (mMRs)