User:Cris Scavone

Degree in Pharmacy and Biochemistry from the University of São Paulo (USP), Master and Ph.D. in Pharmacology from USP, and Post-doctorate from the Massachusetts General Hospital - Harvard Medical School, Boston, USA. Associate-Professor at USP (2003) and Member of the São Paulo State Academy of Sciences (2012) and Head of Department of Pharmacology (2013-2017). He is currently a Professor of the Department of Pharmacology of the Institute of Biomedical Sciences at USP (2009-). Contributed in the field of Pharmacology and Neuroscience with emphasis on aging and signaling cascade linked to degenerative diseases by introducing new knowledge in studies of adaptive responses associated with hormesis and cognition involving cardiotonic steroids, glucocorticoids, Klotho protein, glutamate and non-pharmacological strategies, such as intermittent fasting and physical exercise. Research Laboratory employs a multifaceted array of experimental models of aging and age-related neurodegenerative disorders in order to establish the molecular and biochemical changes that occur during aging and in disorders such as Alzheimer’s and Parkinson’s diseases. An area of focus is aimed at understanding adaptive cellular stress responses in neurons, and how they can be activated by behavioral and pharmacological interventions so as to protect the brain against injury and disease. Data obtained in these experimental models are integrated with data obtained in studies of both normal elderly humans and patients with neurodegenerative disorders to arrive at conclusions as to why neuronal dysfunction and degeneration occur in the disorders. Discoveries made in animal models in the laboratory are being translated into preclinical studies and clinical trials in human subjects.