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Diagnosis
Healthcare providers may screen patients for depression using a screening tool, such as the Patient Healthcare Questionnaire-2 (PHQ-2).

To diagnose a major depressive episode, a trained healthcare provider must make sure that:
 * The symptoms do not meet the criteria for a mixed episode.
 * The symptoms must cause considerable distress or impair functioning at work, in social settings or in other important areas in order to qualify as an episode.
 * The symptoms are not due to the direct physiological effects of a substance (e.g., abuse of a drug or medication) or a general medical condition (e.g., hypothyroidism).
 * Other than in the case of severe symptoms (severely impaired functioning, severe preoccupation with worthlessness, ideas of suicide, delusions or hallucinations or psychomotor retardation).