User:D'on Chang/sandbox

Structure and Function[edit | edit source]

Ubiquitin-conjugating enzyme E2 variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene also shares homology with ubiquitin-conjugating enzyme E2 variant 1 and yeast MMS2 gene product. It may be involved in the differentiation of monocytes and enterocytes.[5]

'''UBE2V2 has been implicated as an intracellular sensor of reactive electrophilic species, which are present in high levels during periods of pathogenic and/or environmental stress. (1) The C69 residue of UBE2V2 is capable of binding with various RES. It has been shown that binding of RES to UBE2V2 promotes UBE2V2-mediated activation of Ube2N, another E2 protein that complexes with UBE2V2. Activated Ube2N has been shown to play a major role in promoting DNA-damage responses. Thus, UBE2V2 may promote genome integrity by directly sensing RES and effecting DNA damage responses.'''

UBE2V2 activity has also been shown to affect innate immunity by acting as a regulator of NF-kB

Interactions[edit | edit source]

UBE2V2 has been shown to interact with HLTF.[6]

UBE2V2 can form a heterodimeric complex with UBE2N to cooperatively form K63 polyubiquitn chains with TRIM1.

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