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Zero to Three National Center for Infants Toddlers and Families, formerly the National Center for Infants, Toddlers, and Families, commonly known as Zero to Three and stylized as ZERO TO THREE, is a US nonprofit organization focused on the healthy development of babies and toddlers from birth to three years old. The organization participates in policy advocacy, provides professional development for early childhood professionals, and operates programs related to children’s health and welfare in a number of states. Zero to Three also publishes a variety of resources for parents, professionals and policy makers, most notably the DC:0–5™ Diagnostic Classification of Mental Health and Developmental Disorders of Infancy and Early Childhood. The organization’s research is widely cited in the field of early childhood development and infant health.

Diagnostic Manual
In 1987, Zero to Three convened a group of clinicians and researchers in the United States, Canada and Europe to develop a mental health classification system for infants and toddlers. After conducting literature reviews and considering case reports and clinical experiences, the task force members identified diagnostic categories and specific patterns of emotional and behavioral problems. The first edition of the manual, DC:0–3 Diagnostic Classification of Mental Health and Developmental Disorders of Infancy and Early Childhood, was published in 1994; in 2021 it was expanded to include children from ages zero to five.