User:DSchlink15/Evaluate an Article

Which article are you evaluating?
Hexokinase - Wikipedia

Why you have chosen this article to evaluate?
Kinases are a common enzyme type I feel comfortable with. They are important for activating or deactivating molecules or other enzymes. For example, hexokinase is needed to allow cells to avoid diffusion troubles and continually pull more glucose into the cell. The article overall is decently in-depth content wise, but a lot of the claims do not have sources supporting them.

Evaluate the article
 Lead 

The introductory sentence is well written and explains the very basic function of this enzyme. The section talking about the difference between glucokinase and hexokinase seems out of place in the lead section. Instead, maybe mentioning the fact that there are different isoforms and then leaving further explanation for a different section.

 Content 

All of the sections going into more detail are relevant. All the content is up to date. One source is from 1977 so could possible use updating but all the other sources are more recent. The article does a good job of using a neutral tone. No agendas were pushed and that the author avoided biases in the article.

 Sources and References 

A number of areas are in need of sourcing. Some of the basic facts should still use literature to support the claims. One of the claims used a paper published in 1977. Updating this if there is more modern research would be a good idea. All three of the links I tried were still functioning and seem to be open source meaning access is available to anyone. Source 6 needs checked both the claim and a way to access the source since the link is no longer working.

 Organization and writing quality 

The article is well written. The sections are well-organized but could use some further elaboration. I did not notice any errors within the article that would need fixed.

 Images and Media 

Pictures of the 3D structure of this protein are included. They also have a picture that shows the reaction this enzyme catalyzes. All of the pictures have well written captions explaining the images.

 Talk page discussion 

There is some discussion of the substrates of hexokinase. A comment from 2017 also asked that is be simplified more so people who struggle with biochemistry can better understand it. This article is rated as a B-class article of mid-importance. It's a part of the molecular and cellular biology wikiproject.

 Overall impressions 

Overall, the article is good with some minor things which could be modified. The Variation subsection could better go into the different isoforms of hexokinase instead of creating another header for mammalian forms of hexokinase. An explanation of what an actin fold protein and a source for that claim would help. The article barely touches on what hexoses are. Explanation of that and some examples of different hexoses would be helpful. In the consequences of phosphorylation section, it should also mention the effect this has on the concentration gradient for moving glucose into the cell. Hydropathy analysis could use some tweaking to ensure the point is supported.