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Coiled-coil domain containing protein 180 (CCDC180)
Coiled-coil domain containing protein 180 (CCDC180) is a human protein of unknown function that is encoded by the CCDC180 gene located on chromosome 9. It is also known by the aliases KIAA1529, BDAG1, and C9orf174.

Gene Features
The gene encoding this protein is 71,221 bases long, and the mRNA transcript is 5,635 bases long and contains 48 exons.

Protein Features
The CCDC180 protein contains 1,701 amino acids. The protein contains two conserved domains of unknown function, designated DUF4455 and DUF4456. There are also two coiled-coil domains and a glucine-rich domain.

Homology
There are no paralogs for this gene, but there are orthologs in a wide variety of organisms, extending back to single-celled green algae. CCDC180 is not conserved in bacteria, archaea, plants, fungi, or protists. The following table includes a subset of species containing orthologs of CCDC180. It is not exhaustive, but it indicates the variety of species containing orthologs of CCDC180.

Evolutionary History
CCDC180 is a relatively quickly-evolving gene compared to other well-known genes. There are no known family members, splice variants or isoforms, or evidence of gene duplications in the history of the gene.

Disease Association
A single-nucleotide polymorphism (SNP) in the gene has been shown to be significantly associated with Behcet's disease, and this designation led to the proposed alias Behcet's disease-associated gene 1 (BDAG1). The gene has been shown to be over-transmitted in families with two or more siblings affected by both cleft lip/palate and dental abnormalities. This gene is also indicated to be over-expressed in the peripheral blood mononuclear cells (PBMCs) of patients with bipolar disorder.