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Telomeric repeat-binding factor 2 is a protein that is also known as TRF2 and TRBF2. It is in humans encoded by the TERF2 gene.

Function
This gene encodes a telomere specific protein, TERF2, which is a component of the shelterin nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic.

Interactions
TERF2 has been shown to interact with:
 * Ku70,
 * MRE11A,
 * Nibrin and
 * Rad50,
 * TERF2IP,   and
 * Werner syndrome ATP-dependent helicase.