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The first settlement that would become the American city of Seattle was established in 1852 by members of the "five founding families", a group of pioneers led out of Cherry Grove, Illinois by Arthur A. Denny. Though originally named Duwamps, the settlement's name was changed to Seattle in 1853, in honor of Chief Seattle, the ruler of the nearby Suquamish and Duwamish tribes.

A number of buildings, locations, businesses, and other things in and around Seattle are currently named for members of the five families. The patriarchs of all of the founding families, and many of their descendants, are buried in Lake View Cemetery, a prestigious cemetery in Seattle's Capitol Hill neighborhood where almost all people of importance in the city's history are interred.

Denny
Known as "Seattle's first family", in 1851 Denny family patriarch Arthur A. Denny led the five founding families from Cherry Grove, Illinois to the site of what would become Seattle. As of 2014, family scion Zach Cook was Market Master at the Pike Place Market.