User:DavidLang1973/Acetylpropionyl

2,3 pentanedione

Acetylpropionyl is used in food production facilities such as those which manufacture cookies, coffee, cereal and chocolate. It is also found in nicotine containing liquids used for vaping and flavored cigarettes.

There is substantial evidence of the pulmonary toxicity of Acetylpropionyl in animals. Rats exposed to acetylpropionyl develop both fibrosis and necrosis of the respiratory tract. Mice exposed to acetylpropionyl demonstrate more bronchial constriction in response to methacholine challenge.

Acetylpropionyl has been used as a substitute for the toxic flavoring chemical diacetyl. However, in one flavoring manufacturing facility which had substituted diacetyl for acetylpropionyl, abnormal lung function values were associated with total time spent in production areas. An investigation by NIOSH in 2009 at a facility which used buttermilk flavoring containing acetylpropionyl demonstrated that workers had higher than average reports of shortness of breath, asthma, and restrictive type spirometry defects. Another investigation by NIOSH in 2013 at a flavoring manufacturer which utilized acetylpropionyl revealed that those workers who had spent the most time working with flavoring chemicals were more likely to have abnormal lung function as detected by pulmonary function tests.