User:Daviddecraene

Who am I?
Ph. D. Biomedical Sciences. Owner of Ontology Online Creator of jOWL - semantic javascript library.

Expertise in the following fields:
 * Signal Transduction
 * Carcinogenesis
 * Formal Ontology
 * Expertise in modeling and management of large-scale Ontologies

Currently employed by Language and Computing.

Biomedical sciences
Decraene D. et al JID 125(5): 1026-31. 2005. A low UVB dose, with the potential to trigger a protective p53-dependent gene program, increases the resilience of keratinocytes against future UVB insults.

Decraene D. et al JID 123(1): 207-12. 2004. AKT status controls susceptibility of malignant keratinocytes to the early-activated and UVB-induced apoptotic pathway.

Decraene D. et al JID 122(2): 484-91. 2004. A synthetic superoxide dismutase/catalase mimetic (EUK-134) inhibits membrane-damage-induced activation of mitogen-activated protein kinase pathways and reduces p53 accumulation in ultraviolet B-exposed primary human keratinocytes.

Decraene D.et al JBC 277(36): 32587-95. 2002. Insulin-like growth factor-1-mediated AKT activation postpones the onset of ultraviolet B-induced apoptosis, providing more time for cyclobutane thymine dimer removal in primary human keratinocytes.

Decraene D. et al J Photochom & Photobiol. 63(1-3):78-83. 2001. Acute response of human skin to solar radiation: regulation and function of the p53 protein.

Claerhout S., Decraene D.et al JID, advance online publication. august 2006. AKT Delays the Early-Activated Apoptotic Pathway in UVB-Irradiated Keratinocytes Via BAD Translocation.

PH.D. Dissertation: The UVB-response in human skin and its modulation by the proto-oncogenic AKT signaling pathway.

Ontology
The Methodology behind the Military Health System Conceptual Framework and Core Ontology. Mariana Casella dos Santos, Christoffel Dhaen, David Decraene, Maria van Gurp, Tom Deray.

CliniComp Terminology Mapping: Methodology David Decraene, Karen Doyle, Dave Hellman & Mariana Casella dos santos.